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Alnyam and PeptiDream Sign Collaboration Agreement to Discover and Develop Peptide-siRNA Conjugates for Targeted Delivery of RNAi Therapeutics to Broader Extrahepatic Tissues BioSpace

Uplifting message in 3 photos (3)CAMBRIDGE, Mass. & KAWASAKI, KANAGAWA, Japan--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (NASDAQ: ALNY ), a leader in RNAi therapeutics, and PeptiDream, Inc. .(TSE: 4587), a leading peptide-based drug discovery company and its Peptide Discovery Platform System (PDPS), today announced a licensing and collaboration agreement to discover and develop peptide siRNAs to create additional opportunities to Extrahepatic tissues deliver RNAi therapy. .Through this collaboration, the companies will jointly select and optimize peptides for the targeted delivery of small RNA interference (siRNA) to a variety of cell types and tissues through targeted interactions with receptors expressed on target cells.

Under the terms of the alliance, Alnylam will select a group of recipients for PeptiDream's peptide discovery platform. PeptiDream will select, optimize and synthesize peptides for each receptor. Will Alnylam then generate the peptide-siRNA conjugate and execute it?in vitro? Yeah?direct• Studies to support the final selection of peptides. By targeting disease-causing mRNA transcripts in a variety of different tissue types, the collaboration has the potential to generate additional therapeutic options. After solving the delivery problem of RNAi therapeutics to the liver and making major preclinical progress?direct? We are now adding delivery to the central nervous system, eye and lungs to our suite of delivery technologies that have the potential to enable effective delivery of siRNA to a wider range of tissue types throughout the human body? said Dr. Kevin Fitzgerald, Alnylam's chief scientific officer. "We are pleased to enter into this research collaboration agreement with PeptiDream, an industry leader in the discovery and optimization of peptide ligands for multiple receptors. Through this collaboration, we hope to identify robust ligands for extrahepatic tissue delivery -receptor pair, similar to the GalNAc-ASGPR pair, we have pioneered highly efficient liver delivery "This agreement further expands our use of peptides to deliver multiple therapeutic payloads to diseased cells (e.g. peptide-drug conjugates) strategy. /tissue is targeted. We hope this partnership will lead to the creation of innovative peptide-siRNA conjugates in multiple diseases and unlock many new therapeutic opportunities. Under the terms of the agreement, PeptiDream will receive an upfront payment from Alnyam as well as research and development funding during the term. Research collaborations as stipulated in the agreement. PeptiDream may also receive payments depending on the achievement of certain development, regulatory and commercial milestones, which may amount to up to DKK 2.2 billion. US dollars ($244 billion*1). In addition, PeptiDream is entitled to receive low to mid single digit royalties on the sale of these Alnylam products. *1: USD/JPY exchange rate: 110.9About RNAiRNAi (RNA interference), a natural cellular gene silencing process, represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Their discovery has been hailed as "a major scientific breakthrough that occurs about every ten years"? And won the 2006 Nobel Prize in Physiology or Medicine. By harnessing the natural biological process of RNAi that occurs in our cells, a new class of medicines called RNAi therapeutics is now a reality. Small RNA interference (siRNA), the molecule that mediates RNAi and constitutes Alnylam's RNAi therapeutics platform, works upstream of current drugs by effectively silencing messenger RNA (mRNA)? genetic precursor? They encode disease-causing proteins, which prevent them from happening. It's a revolutionary approach that has the potential to change the treatment of patients with genetic and other disorders.Om Alnylam PharmaceuticalsAlnylam (Nasdaq: ALNY) is leading the translation of RNA interference (RNAi) into a new class of innovative medicines with the potential to transform the lives of people with rare genetic, cardiometabolic, infectious liver and central nervous system diseases. (CNS) / eye disease. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful and clinically proven approach to treating a variety of serious and debilitating diseases. Founded in 2002, Alnyam has a bold vision to turn scientific opportunity into reality through a powerful RNAi therapeutics platform. Alnylam's commercial RNAi therapy is ONPATTRO? (patisirán), GIVLAARI? (givosiran), OXLUMO? (lumasiran) and Leqvio? (inclisiran) is developed and marketed by Alnylam's partner Novartis. Alnylam has a large pipeline of investigational drugs, including six late-stage drug candidates. Alnylam rides on its ?Alnylam P5x25? A leading biotech profile with a strategy to deliver transformative medicines for rare and common diseases, benefiting patients worldwide through sustainable innovation and superior financial performance. Alnylam is headquartered in Cambridge, Massachusetts. To learn more about our people, science and pipeline, visit ?www.alnylam.com? And engage with us on Twitter?@Alnylam, I?LinkedIn, Yes?instagram.Om PeptiDream, Inc.PeptiDream, Inc., a publicly traded biopharmaceutical company (TSE: 4587) founded in 2006, has deployed its own Peptide Discovery Platform System (PDPS), a state-of-the-art highly versatile discovery platform capable of producing non-peptide discovery platform systems Standard high potency peptides are used to identify high potency and selectivity successful candidates, which can then be developed into peptide, small molecule or peptide-drug conjugate based therapies. PeptiDream strives to be a world leader in the discovery and development of medicines to address unmet medical needs and improve the quality of life of patients worldwide. For more information, please visit ?https://www.peptiddream.com.Alnylam Forward-Looking StatementsVarious statements in this press release relate to Alnylam's expectations, plans, aspirations and goals, including statements related to PeptiDream's license and collaboration agreement, and the discovery and development of powerful siRNA-peptide conjugates to create additional opportunities to incorporate RNAi The ability of the therapy to deliver to a broad population of non-liver tissue types, the potential for future milestone and royalty payments to PeptiDream and the planned acquisition of our ?Alnylam P5x25? strategy, which constitutes forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Actual results and future plans may differ materially from those indicated in these forward-looking statements due to a variety of significant risks, uncertainties, and other factors, including but not limited to: the global COVID-19 pandemic or any future pandemic The direct or indirect impact of the pandemic on the Company, Alnylam's operating results and financial condition, and the effectiveness or timeliness of Alnylam's efforts to mitigate the impact of the pandemic; Alnylam discovers and develops new drug candidates and methods of delivery and successfully demonstrates the efficacy and safety of its product candidates; the preclinical and clinical results of its product candidates; actions or recommendations by regulatory agencies, and Alnylam's ability to obtain and maintain regulatory approvals and favorable pricing and rebates for its product candidates; globally Successful launch, marketing and sale of its approved products; delays, interruptions or failures in manufacturing and delivery of its product candidates or their marketed products; acquisition, maintenance and protection of intellectual property rights; successful future expansion of ONPATTRO (or vutrisiran, if approved) by Alnylam Indication; Alnylam's ability to manage its growth and operating expenses through disciplined operating investments, and its ability to achieve a self-sustaining financial position without the need for equity financing in the future; Alnylam's ability to maintain strategic business partnerships; Alnylam's reliance on third parties proceed with the development and commercialization of certain products, including Novartis, Regeneron and Vir; trial results; risks of government investigations; and unexpected expenses; and risks discussed in more detail under "Risk Factors." Filed with Alnylam's most recent quarterly report on Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) and other filings with the SEC. In addition, any forward-looking statements represent Alnyam's views only as of today and should not be relied upon as its views at any time in the future. Alnylam specifically disclaims any obligation to update any forward-looking statement, except to the extent required by law.Uplifting message in 3 photos (4)

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contact person

Alnylam PharmaceuticalsChristine Regan Lindenboom (Investors and Media) 617-682-4340Josh Brodsky (Investors) 617-551-8276PeptiDream CompanyYuko OkimotoIR and Public Affairs[email protected]

(Video) Overcome Negative Thoughts | Best Motivational Video For Positive Thinking


What are some good quotes for pictures? ›

Cute Selfie Captions
  • “If you were looking for a sign, here it is.”
  • “Remember that happiness is a way of travel – not a destination.”
  • “Just because you're awake doesn't mean you should stop dreaming.”
  • “Be yourself, there's no one better.”
  • “Stress less and enjoy the best.”
  • “Look for the magic in every moment.”
Jan 6, 2023

What are 3 powerful motivational words? ›

Short motivational quotes
  • “Just one small positive thought in the morning can change your whole day.” — ...
  • “Opportunities don't happen, you create them.” — ...
  • “Love your family, work super hard, live your passion.” — ...
  • “It is never too late to be what you might have been.” —
Dec 1, 2022

What is a good short positive message? ›

You're braver than you believe, and stronger than you seem, and smarter than you think. Keep your face to the sunshine and you cannot see a shadow. In every day, there are 1,440 minutes. That means we have 1,440 daily opportunities to make a positive impact.

What is a good 3 word quote? ›

Seize the day.” “Shine your light.” “Creativity takes courage.” “Don't overthink it.”

What do you say to a beautiful picture? ›

Tell her you love to see her happy.
  • You could say, “You have such a gorgeous smile. Seriously.”
  • You could also try, “You have the most beautiful smile I've ever seen!”

What are the 5 positive quotes? ›

You can do it quotes
  • “Do the best you can. ...
  • “Do what you can, with what you have, where you are.” ―Theodore Roosevelt.
  • 'It's never too late to be what you might've been.” ―George Eliot.
  • “If you can dream it, you can do it.” ―Walt Disney.
  • “Trust yourself that you can do it and get it.” ―Baz Luhrmann.
May 24, 2022

What is the most inspiring quote ever? ›

What is the most inspiring quote ever?
  • “Our greatest glory is not in never falling, but in rising every time we fall” – Confucius.
  • “Magic is believing in yourself. ...
  • “All our dreams can come true, if we have the courage to pursue them” – Walt Disney.
  • “The real test is not whether you avoid this failure…
Aug 19, 2021

What is a positive quote for life? ›

Life becomes easier and more beautiful when we can see the good in other people.” “Success is not how high you have climbed, but how you make a positive difference to the world.” “Pursue what catches your heart, not what catches your eyes.” Your hardest times often lead to the greatest moments of your life.

What are 2 inspirational quotes? ›

Motivational quotes to start your day
  • “You can get everything in life you want if you will just help enough other people get what they want.” — ...
  • “Inspiration does exist, but it must find you working.” — ...
  • “Don't settle for average. ...
  • “Show up, show up, show up, and after a while the muse shows up, too.” — ...
  • “Don't bunt.
May 18, 2020

How do you write an uplifting message? ›

Sprinkle these phrases in your words of encouragement card.
  1. “I know you can do it!”
  2. “You've got this!”
  3. “You have everything you need to get it done!”
  4. “You're stronger than you think.”
  5. “If anyone can do this, it's you.”
  6. “I believe in you!”
  7. “Be brave and make it happen!”
  8. “You're worthy of everything you want.”

What are the three most important words in life? ›

For all those who see opportunity-and everyone who wants to-comes the greatest support system ever bound between two covers: The Three Most Important Words in Life Are Attitude, Attitude, Attitude.In these pages, winners - and those who want to be - will find some of the most profound quotations, thoughts, and ...

What is a peaceful quote? ›

Not one of us can rest, be happy, be at home, be at peace with ourselves, until we end hatred and division.” —John Lewis. “You cannot shake hands with a clenched fist.” ―Indira Gandhi. “When you make peace with yourself, you make peace with the world.”

How do you describe a perfect picture? ›

Synonyms of picture-perfect
  1. perfect.
  2. ideal.
  3. flawless.
  4. excellent.
  5. immaculate.
  6. superb.
  7. prime.
  8. unblemished.

How do you compliment a beautiful picture in one word? ›

Beautiful / Stunning / Lovely — Pleasing to the senses or the mind; exceptionally attractive or pretty; impressive; mind-blowing; radiant.

What is a happy quote? ›

Happiness is when what you think, what you say and what you do are in harmony.

What's the most powerful quote? ›

  1. 21 Of The World's Most Powerful Quotes, Updated For Today. ...
  2. “You must be the change you wish to see in the world.” ...
  3. “Everybody is a genius. ...
  4. “A life spent making mistakes is not only more honorable, but more useful than a life spent doing nothing.” ...
  5. “He who fears he will suffer, already suffers because he fears.”

What are some short good happy quotes? ›

Happiness Quotes
  • “The most important thing is to enjoy your life – to be happy. ...
  • “Nothing can bring you happiness but yourself.” – ...
  • “Never regret anything that made you smile.” – ...
  • Today I will focus on stressing less and feeling blessed.
  • “Happiness is the best makeup.” – ...
  • “Happiness is a state of mind.

What are 10 good quotes? ›

10 famous quotes by celebrities
  • "I'm not here to be perfect, I'm here to be real." - ...
  • "I'm not interested in money. ...
  • "The only thing that feels better than winning is winning when nobody thought you could." - ...
  • "Success is not final, failure is not fatal: It is the courage to continue that counts." -
May 20, 2022

What is a beautiful life quote? ›

“Life is abundant, and life is beautiful. And it's a good place that we're all in, you know, on this earth, if we take care of it.” “Keep your head high, keep your chin up, and most importantly, keep smiling, because life's a beautiful thing and there's so much to smile about.”

What do you say to motivate someone? ›

These phrases are ways to tell someone to keep trying:
  • Hang in there.
  • Don't give up.
  • Keep pushing.
  • Keep fighting!
  • Stay strong.
  • Never give up.
  • Never say 'die'.
  • Come on! You can do it!.

What are the wise words? ›

35 Words of Wisdom You Will Never Forget
  • You create your own opportunities. ...
  • Never break your promises. ...
  • You are never as stuck as you think you are. ...
  • Happiness is a choice. ...
  • Habits develop into character. ...
  • Be happy with who you are. ...
  • Don't seek happiness–create it. ...
  • If you want to be happy, stop complaining.

What is a strong woman quote? ›

A strong woman knows she has strength enough for the journey, but a woman of strength knows it is in the journey where she will become strong.

What are positive messages? ›

Positive messages include messages where the audience is expected to react in a neutral to positive manner. Positive messages tend to consist of routine or good news. These messages might be items such as congratulations, confirmations, directions, simple credit requests, or credit approvals.

What are 20 positive quotes? ›

Top 20 Motivational Quotes
  • It's not the size of the dog in the fight, but the size of the fight in the dog. ...
  • Nothing lasts forever. ...
  • There are only two ways to live your life. ...
  • Take chances, make mistakes. ...
  • Being strong means rejoicing in who you are, complete with imperfections.

What is a short quote? ›

Short quotations contain less than 40 words. For short quotations, write quotation marks ("...") around the words and incorporate the quote into your text. Include page numbers in the text citation.

What are empowering quotes? ›

Empowering Quotes for Self-Worth

No one can make you feel inferior without your consent.” “You yourself, as much as anybody in the entire universe, deserve your love and affection.” “Self–worth is so vital to your happiness if you don't feel good about yourself, it's hard to feel good about anything else.”

What's something uplifting to say? ›

This is tough, but you're tougher.” “I'm proud of you for walking this road, for doing what's right for you.” “You're making a big change, and that's a really big deal.” “I know what you're going through is hard, but I'm rooting for you every minute of every day.”

What are three words that go together? ›

Remember that the linking word may appear either before or after each word in the triplet:
Feb 13, 2015

Can a phrase be 3 words? ›

Three word expressions are common in English. Practising them and using them when you speak will help you sound more natural. Here are ten common English expressions, along with an explanation and example sentence.

What are some 4 word quotes? ›

'Encourage Everyone in 4 Words' -- 50 Most Inspiring Phrases From the Viral Trend
  • Don't worry, be happy.
  • You're not dead yet.
  • Don't give up, ever.
  • Dream big, believe bold!
  • You deserve some cake.
  • I appreciate your work.
  • Just drink more coffee.
  • Let's do this now.
Mar 3, 2015

What are the 3 golden words? ›

Please, sorry and thank you are known as the Golden Words. Using these three words means you have good manners.

What are the 3 words that can change your life forever? ›

The 3 Words That Can Change Your Life
  • "I" very simply represents you as the agent.
  • "am" represents your beliefs about who you are presently.
  • "can" represents your beliefs about what you are capable of doing in the future.
Mar 28, 2016

What is life all about 3 words? ›

Intelligence. Usefulness. Responsibility. Yes, the meaning of life is to work towards intelligence, usefulness and responsibility.

What's a good personal quote? ›

Take responsibility of your own happiness, never put it in other people's hands.” “How wonderful it is that nobody need wait a single moment before starting to improve the world.” “You cannot find peace by avoiding life.” “Treat everyone with politeness and kindness, not because they are nice, but because you are.”

What are 4 quotes on peace? ›

Peace Quotes
  • Peace cannot be kept by force; it can only be achieved by understanding. ...
  • Peace is not absence of conflict, it is the ability to handle conflict by peaceful means. ...
  • People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf. ...
  • Peace comes from within.

What is a quote for calmness and strength? ›

Inspiring quotes on calmness

Gentleness is strength under control. It is the ability to stay calm, no matter what happens.” “By staying calm, you increase your resistance against any kind of storms.” “Breath is the power behind all things….

What should I say on my pictures? ›

You can use these captions to inspire your followers to reach their goals.
  • Happy days are here again!
  • A better version of me.
  • I just leveled up.
  • Life won't get easier. ...
  • I'm built from every mistake I have ever made.
  • Be the best version of you.
  • Make today so awesome that yesterday becomes jealous.
  • I'm on top of the world.
3 days ago

What is a cute caption? ›

Cute selfie captions:

"Never let anyone treat you like you're ordinary." "Be yourself, there's no one better." "She acts like summer and walks like rain." "Life is better when you're laughing." "Be more of you, and less of them."

What is a good uplifting quote? ›

Always work hard and have fun in what you do because I think that's when you're more successful. You have to choose to do it.

What is the most inspirational message? ›

Our greatest glory is not in never falling, but in rising every time we fall” – Confucius. “Magic is believing in yourself. If you can do that, you can make anything happen” - – Johann Wolfgang von Goethe. “All our dreams can come true, if we have the courage to pursue them” – Walt Disney.

How do you write good pictures? ›

How to write from picture prompts?
  1. Have a good look. An exciting or deceptively simple photo can be an inspiration for you. ...
  2. Take some time to absorb the photo details. ...
  3. Experience the photo through your senses, and form the words. ...
  4. Start writing. ...
  5. Keep writing and also start editing.

What can I write instead of nice pictures? ›

List search
23»good picture exp.
10»beautiful image exp.
10»good shot exp.
9»lovely photo exp.
8»good one exp.
16 more rows

What are some cute quotes to say? ›

Short Love Quotes
  • “Love all, trust a few, do wrong to none.” – ...
  • “You call it madness, but I call it love.” – ...
  • “We can only learn to love by loving.” – ...
  • “A life lived in love will never be dull.” – ...
  • “Life is the flower for which love is the honey.” – ...
  • “All you need is love.” – ...
  • “True love stories never have endings.” –
Apr 26, 2023

What are some classy captions? ›

Elegant Captions For Instagram
  • Be yourself; there's no one better.
  • The finer things in life.
  • Darling, I chase goals, not people.
  • Timeless style.
  • Embrace the glorious mess that you are.
  • Lost in a world that doesn't exist.
  • Timeless beauty.
  • Cutie with a mission. Hottie with ambition.
Jan 21, 2023


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