Ludwig Boltzmann Society - PDF Free Download (2023)


1Ludwig Boltzmann Society

2Ludwig Boltzmann Society Overview LBG LBG Office It is headed by two managing directors. It is the senior management and administrative body of LBI and LBC. She supports them on strategic and administrative matters. Contracts and personnel management Controlling and accounting Joint PR work Legal form Legal form of the LBG Board of Directors LBG is an association with a limited liability company as a 100% subsidiary. LBIs and LBCs have legal representation in associations (LBI and LBC) or limited liability companies (LBI only). All LBIs related to public tenders since 2005 belong to LBG GmbH. The LBG Office is equally responsible for associations and LLCs. Survey Claudia Lingner Management Erich Heiss Management LBG Survey It is conducted by LBI and LBC. Health Sciences _ Musculoskeletal Research _ Cardiovascular Research _ Oncology Research Human, Social and Cultural Sciences _ Linguistics and Literature _ History and Archaeology _ Law Focus: Translational and Collaborative Research LBG LBI and LBC have partners from a wide range of fields. Partners are organizations (eg universities, companies, museums) that conduct and apply research. Partners contribute to a joint and coherent research program and as joint partners are part of the limited liability company LBI, typically contributing 60% of the financial resources. They are partners of the LBI and LBC in an association without predetermined rules, like the LBI of the GmbH. LBG Board of Directors It is the controlling and decision-making body under the LBG Office. Association members elect 12 board members every three years. LBG LBI LBC Josef Proell President Wolfgang Hesoun Vice President Gabriele Zuna-Kratky Vice President Johann Marihart Vice President Sabine Herlitschka Vice President Christoph Neumayer Christian Rainer Financial Supervisor Ferdinand Maier Second Assistant Financial Director Michael Stampfer Secretary Helmut Miernicki Secretary Sybille Straubinger's board of directors Ludwig Boltzmann Society Ludwig Boltzmann Institute (e) Ludwig Boltzmann -klygen Catalog Foreword...4 About the Ludwig Boltzmann Society...6 Characteristics of the LDwig Boltzmann Society...6 Organization Chart...7 Activities and Processes of the Ludwig Boltzmann Community Strategic Documents...8 Intellectual Capital Report...9 LBG Network...9 Information on Horizon Inventions...10 Evaluation and Quality Assurance...10 Professional Development...12 Scientific Events...17 Public Relations ...19 Ludwig Boltzmann Institute and Cluster...21 LBI Archaeological Exploration and Virtual Archeology...22 LBI COPD and Pulmonary Epidemiology...24 LBI Electrical Stimulation and Physical Rehabilitation...26 LBI Experimental and Clinical Trauma study. ..28 LBI History and Biographical Theory...30 LBI Health Promotion Research...32 LBI Health Technology Assessment...34 LBI Forensic Clinical Imaging...36 LBI Cancer Research...38 LBI Pulmonary Vascular Research... 40 LBI Human Rights...42 LBI Neolatin Research...44 LBI Surgical Laparoscopy...46 LBI Osteology...48 LBI Retinology and Biolaser Microsurgery...50 LBI Social Psychiatry...52 LBI Translational Heart Failure Research...54 LB Cluster History...56 LB Cluster Cardiovascular Research...58 LB Cluster Oncology...60 LB Cluster Rheumatology, Balneotherapy and Rehabilitation...62 LB Cluster Translational Oncology ..64 Facts and Figures LBG Budget. ..70 LBG Staff Summary...71 Overview of LBG Scientific Activities...74 Publications...76 Events...77 Public Relations/Media Vibes

3In a word... JOSEF PRÖLL, President I was particularly impressed by the dynamism with which certain projects were carried out by the LBG last year. In the spring of 2013, the institute's directors met with LBG management at a multi-year management workshop that gave impetus to the process. I have several fond memories of the workshop. On the one hand, I enjoyed experiencing how LBG leaders form a community and how well they communicate. On the other hand, I was very impressed with the outcome of this workshop: co-creation and development of ideas, which eventually led to concrete projects. For example, the LBG successfully launched a project on the topic of open innovation, an idea that was first born at a workshop. Launched this year, the program will further strengthen LBG's new focus on health sciences. Through open innovation, we want to ask new relevant questions for different players in the healthcare industry and find answers together. An exciting innovation process that has never existed in this form before. Furthermore, in order to represent the high-quality work of our Institute, we took steps last year to be able to present their scientific output for the first time in the LBG Knowledge Account. Together with a working group of department heads and experts, we developed the indicators that we now inform for the 2013 research year. We provide excerpts of this in the statistics section of this annual report. What ultimately struck me the most was LBG's strong sense of community. Our researchers do not conduct their research alone in prestigious ivory towers, but within a strong network of partners and collaborations. Each of them monitors the LBG as a whole. Bringing together strengths and creating synergies to further strengthen the position of LBG research in society and science. Especially in an extremely tense economy, this sense of community signals LBG's future goals for financial security. Therefore, we will continue to work together for this dynamic development of LBG. With this strong team behind me, I see a bright future for LBG. CLAUDIA LINGNER, MANAGING DIRECTOR Over the past year, we have focused on fine-tuning our research content and establishing a new focus. In the future, we will focus more on the field of health sciences. The humanities and social sciences are also integrated into new approaches based on interdisciplinary answers to research questions. Our first LBG Health Science Conference in December 2013 opened new directions and we could show that we already had a strong research institutional base in the field. The conference focuses on the scientific exchange between the individual Ludwig Boltzmann Institutes (LBIs) and clusters (LBCs), but is also an opportunity to exchange ideas and think about new collaborations. In the future, we hope to make this event a regular part of the LBG calendar and open the session to other stakeholders from the research community. The further development of our partner network is very important to us, which means especially the integration of new partner organizations into LBI. This partnership means jointly developing and addressing a coherent research program. In addition to special expertise, each partner provides structural and financial resources. Last year we won new partners for three of the LBIs, or thus created new research structures. For example, clinical forensic imaging LBI was introduced to the Home Office to better coordinate the use of new methods in the field of victim protection with police investigative activities. LBI for Archaeological Surveys and Virtual Archaeology has won the Norwegian municipality Vestfold Fylkeskommune as a consortium partner, with which LBI is already working closely on surveys of Viking Age sites in southern Norway. From the point of view of establishing new research structures, the LBI for Health Technology Assessment has become an important player in Austrian health and wellness policy as a partner. From an initial partnership model with individual health system partners, to a new strategic and sustainable partnership with the Federal Ministry of Health, the main associations of social insurance institutions and nine state health funds. The constant growth and further development of LBG requires the conscious use of quality assurance measures. This is why we place particular emphasis on regular assessments of our research facilities. Last year, some LBIs and LBCs passed the evaluation of international experts, and the results have been positive. Strategic and scientific support is also an important asset to LBG as a whole. To this end, we have established a Scientific Advisory Board to support us as an advisory body for the strategic direction of LBG. The five members of the expert advisory board come from the fields of medical and human sciences, social and cultural sciences, and besides professional knowledge, they also have extensive experience in research management. The interdisciplinary composition of the Scientific Advisory Board is also best suited to the LBG's scientific portfolio, with a particular focus on LBG's novel approach to the health sciences. In the following pages of this report you will be able to find out what else happened to LBG in 2013, what research work was carried out as well as figures, figures and facts. Happy reading! four five

4About LUDWIG BOLTZMANN GESELLSCHAFT Office Team LBG Ludwig Boltzmann Gesellschaft Ludwig Boltzmann Gesellschaft (LBG) is a non-university support organization operating research institutes (LBIs) and clusters (LBCs) based on excellence. The LBG initiates innovative research projects of the highest quality together with academic and commercial partners, as well as partners in the public sector. It brings together diverse disciplines and actors to enable independent and socially relevant research in human medicine as well as humanities, social sciences and cultural studies. It is the size of a mid-sized company and its research output has reached critical mass. The Ludwig Boltzmann Institute was established through a transparent tender with an international evaluation procedure. LBI is funded by a consortium of at least one academic partner and one research partner to implement a coherent seven-year research program, often of an interdisciplinary character. The high scientific performance of the institutes has been guaranteed during the call for applications through a two-stage pre-evaluation process supported by an international panel of experts. To ensure continued quality, a mid-term evaluation is carried out after four years and an international scientific committee is established for each institute. LBG operates 17* LBIs and 5 LBCs with approximately 400 actual employees. The LBG is funded by the BMWFW, the National Foundation, the City of Vienna, the state government, municipalities and private sponsors. Features of the LBG The goal of the Ludwig Boltzmann Gesellschaft is to work together in research systems. He hopes to strengthen the University's rankings by increasing research output, establishing new themes and research-related quality drivers, and aligning and linking research activities to the respective priorities and profiles of the University and other research funders. The Ludwig Boltzmann Association has the following characteristics: 1. Incubator function Engine of thematic and structural innovations The Ludwig Boltzmann Institute is designed as an incubator for the sustainable establishment of research and innovation structures. They are complementary/complementary tools to existing portfolios, attempting to create new themes and fix them structurally in the scientific system. 2. A Modern Partnership Model that Guarantees Efficiency and Highly Innovative Research Results The LBG partnership model is characterized by diversity and strategic collaboration, representing an important symbiotic relationship in addressing socially relevant issues. * At the end of May 2013, the LBI ceased its European History and Public Domain activities. Until this point, LBG had operated 18 LBIs and 5 LBCs last year. 3. Translational Research Direct benefit to social issues LBG Institute especially plays a role between basic research and applied research in order to contribute to solving socially relevant problems. However, their research also fits the characteristics of innovation chains. Thanks to interdisciplinary teams, all parts of the chain can be considered, from basic research to applied research to utilization of the results. 4. Interdisciplinary research laboratory for new unconventional problems In LBI, a LBG Association model based on the LBG Association Congress works and selects the most diverse disciplines of LBI LBC MANAGEMENT for joint research programs. Thus, LBG allows thinking styles and methods from different disciplines to be applied to a scientific problem. 5. Focus on Health Sciences LBG's research focus is in the field of health sciences, in addition to the humanities and cultural sciences covering topics such as archaeology, contemporary history, literature, and biography. , because most of the LBI and LBC are already doing research in this area. There, LBG focuses on medical and social science topics. LUDWIG BOLTZMANN SOCIETY Scientific Advisory Board LBG advisor OFFICE LBG _Management _Personnel Administration _Finance / Controlling _Legal agenda _Processes (assessment, knowledge management,...) _Public relations LBI BOARD OF S Advisor LBI LBG GmbH Scientific Advisory Board 10 Ludwig Boltzmann Society Ludwig Boltzmann Society 7

5Ludwig Boltzmann Gesellschaft LUDWIG BOLTZMANN GESELLSCHAFT Activities and Processes In 2013 the LBG Office dealt with the following processes: Creation of a comprehensive strategy document/focus on health sciences Development of indicators for intellectual capital statements in the LGB Further development of the LGBG network. Horizon 2020 supported as new Presentation as part of the EU Program Invention Reporting Evaluation and Quality Control Professional Development Public Relations/Activities Strategy Document As part of a multi-year funding agreement with the Federal Ministry of Science and Research (BMWF)*, the LBG Office prepared a strategy for the period up to 2018 The main content of the file is as follows. The following aspects must be taken into account: Further development of the LBG and positioning in the science and innovation system Topic positioning and planned changes in the research portfolio Excellence positioning and quality assurance Strengthening international cooperation defines the field of health sciences/health sciences. The concept of health science includes all disciplines and fields of study related to health. In addition to public health, medicine, dentistry, pharmacy and nursing sciences, it also includes the reference disciplines of economics (health economics), political science (health policy) and management sciences (health facility management/quality management). Several reasons for deciding to venture into the health sciences. On the one hand, the LBG responds to EU health policy principles in all policy areas, which require effective health policies at national, regional and local levels. Research is one of the policy areas of particular relevance. This is also reflected in Horizon 2020, the EU's new research funding programme, in which health, demographic change and well-being play a major role. On the other hand, the field of health sciences in Austria can be greatly expanded. For this reason, LBG hopes to fill existing gaps in future priority tenders and provide a useful complement to other players in the healthcare industry. Finally, the successful Ludwig Boltzmann study will be brought together thanks to existing health science-focused interdisciplinary research activities, modern and sustainable partnership models that bring together different stakeholders and innovative concepts Integrated into established structures, the LBG is ideal to support prospective studies in the field of organizational health sciences. * Ministry of Science, Research and the Economy (BMFWW) since 2014. Knowledge Balance As part of its funding agreement with BMFF, the LBG has committed to submit a logical outcome-based knowledge statement from 2013 onwards. Both input and output factors representing LBG's scientific performance in 2013 were defined by a working group comprising the Director of the Institute and the Director of the LBG Office. With regard to effect orientation, three effects of LBG were identified, which could be determined using IC statements with key data: 1. High-quality research results (supporting functions) enabled specific research projects. 2. Build an efficient network (bridge function) between academic research institutions and various users/entrepreneurs. 3. Structural development: sustainable establishment of research and innovation structures (structural development function) LBG Network The LBG Network is primarily established through strategic partnerships between the Ludwig Boltzmann Institute and the cluster. In addition, LBI and LBC are connected to many national and international partners that extend the LBG network. But the strategic cooperation should also help international companies maintain their headquarters in Austria. The LBG Office helps its research institutions to further develop their network by contributing its experience to the integration of new partners in the LBI/LBC consortium. It greatly supports department heads in negotiations and joint preparation of contracts. The task of the LBG network also includes strengthening the internal network. Regarding the expansion of the partner network, new organizations were involved last year as alliance partners of three LBIs: 1. LBI Clinical Forensic Imaging In 2013, the Federal Ministry of the Interior (BMI) was able to act as a new Partner. LBI CFI deals with research projects in the field of violence prevention and victim protection. It is in this area that, in addition to the activities of the judiciary, the involvement of the police has proven to be important. The Federal Ministry of the Interior should help to ensure that the development and use of new methods and related procedures are to a greater extent coordinated with police investigative activities for reasons of efficiency. 2. LBI Health Technology Assessment In the case of the Ludwig Boltzmann Institute for Health Technology Assessment (LBI HTA), Austrian health institutions participated as partners in the expansion phase**. From an initial partnership model with individual health system partners, to a new strategic and sustainable partnership with the Federal Ministry of Health, the main associations of social insurance institutions and nine state health funds. 3. LBI Archaeological Survey and Virtual Archaeology In 2013, LBI for Archaeological Survey and Virtual Archaeology (LBI ArchPro) recruited Norwegian municipality Vestfold Fylkeskomune as a consortium partner. Research work on Viking Age sites in southern Norway has been carried out in close cooperation with Vestfold through joint partner NIKU (Norwegian Institute for Cultural Heritage). ** Expansion phase: If the realization of the LBI established as part of the tender is appropriate after the end of the first seven-year limited phase, and the sustainability of the resulting research results is of strategic interest to the partners, up to a further extended for seven years. The ultimate goal should be to integrate research topics and LBI knowledge into partner organizations or transfer to independent structures. To begin the extension, new applications and new concepts must be submitted and reviewed by international experts. 8 Ludwig Boltzmann Society Ludwig Boltzmann Society 9

6Ludwig Boltzmann Society HORIZON 2020 The new EU research and innovation programme, Horizon 2020, runs from 2014 to 2020 and is funded with almost €80 billion. Because LBG is heavily involved in the health sciences, LBG Health's funding priorities should be used in conjunction with funding applications. In this way, LBI and LBC had to connect in an interdisciplinary way before submitting their proposals, in order to gain experience and undertake the management of the project. In order to be as prepared as possible to meet new challenges, the LBG Office together with FFG representatives organized an information workshop on the new EU funding scheme for LBI and LBC. A number of activities are planned after the workshop. Invention reporting The LBG Office supports the LBI/LBC with regard to invention notification by accompanying all relevant processes and coordinating with the Austrian Economic Services Agency (AWS). On the one hand, there is cooperation from invention to notification, and surveillance of consciousness. Jointly organize information events and workshops. The aim is to familiarize LBG researchers with their own research work and resulting inventions, and to fully understand the procedure for registering inventions. In 2013, LBG applied for three patents worldwide. Of these, two applications are related to the field of tissue regeneration by special silk treatments and one is related to endothelial cell-related blood coagulation by the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma) develop. Last July, LBG was also granted an Austrian patent for a method for the non-invasive diagnosis of pulmonary hypertension, developed at the Ludwig Boltzmann Pulmonary Vascular Institute (LBI LVR). Evaluation and Quality Assurance Regular evaluation and, last but not least, consistent implementation of evaluation results aim to ensure that LBG funding is invested in high quality research. The extensive evaluation process is organized by the LBG Office. In January 2013, international experts evaluated the Ludwig Boltzmann Rheumatology, Balneotherapy and Rehabilitation Cluster (LBC RBR). The successful outcome of the evaluation confirms that the cluster will continue to operate for another four years. In November, the Ludwig Boltzmann Institute for Archaeological Exploration and Virtual Archeology (LBI ArchPro) and the Ludwig Boltzmann Institute for Lung Vascular Research (LBI LVR) carried out the first mid-term evaluation. This was planned four years after the establishment of the LBI and took the form of a field trip by independent experts. For each LBI, three international scientists conducting research in the field of the LBI and one evaluation program expert are selected as reviewers. Both LBIs achieved excellent evaluation results. Finally, in December 2013, an international committee of experts evaluated the Ludwig Boltzmann Cluster Oncology (LBC ONC) and the Ludwig Boltzmann Cluster Translational Oncology (LBC TO). LBC ONC has received very positive reviews. LBC TOs were asked to develop an overarching scientific and organizational concept within one year, taking into account expert criticism. This will be evaluated in 2015. LBI ArchPro has proven its ability to survey large areas of the landscape in an extremely short amount of time. This success has been widely recognized. This is essential to the formation of the company and building its reputation. (From: LBI ArchPro assessment) During the first 3.5 years, the institute was assessed as having established a very strong foundation which will lead to excellent research output and increased international visibility in the future. The cornerstone of the site is a first-class infrastructure primarily provided by the Medical University of Graz, strong institutional support from the Ludwig Boltzmann Society, complementary consortium partners, scientific qualifications and qualities of young researchers, and senior personnel experience and leadership skills of researchers. (Excerpt from: LBI LVR Evaluation) In addition to regular evaluations, another quality assurance tool is the establishment of a scientific advisory board. All LBIs established during the Call for Proposals have a Scientific Advisory Board. It consists of five experts who accompany and advise LBI in a scientific way. Advisory Committees meet annually at their respective LBIs. LBG's Scientific Council In 2013, it was decided to create a scientific advisory board for the entire LBG organization. The nominated members have been confirmed: Prof. Dr. Peter-André Alt Literary Researcher and Rector of the Free University of Berlin (Germany) PD DDr. Dr. Georg Friedrich Bauer, health and occupational researcher, professor at the University of Zurich and professor at ETH Zurich (CH). Dr. Helga Nowotny, Sociologist and Researcher, Chairman of the ERA Council Forum Austria Prof. Dr. Babette Simon Physician and Business Economist, Chairman of the Board of Directors of the Medical University of Mainz (Germany) Prof. Dr. Franz Gerhard Walter PhD and Director, International Neuroscience Institute Hannover (Germany) 10 Ludwig Boltzmann Society Ludwig Boltzmann Society 11

7Ludwig Boltzmann Gesellschaft Career Development LBG Course The LBG course is for PhD students training and researching at the LBI/LBC. In the future, they will be able to complete training programs designed to impart complementary skills that were overlooked in specific training. The purpose of the LBG program is to provide additional qualifications for future careers or the labor market after graduation. Bioinformatics Methods and Databases for Molecular Research Prof: Christian Siehs (FH Technikum Wien) Hacking Academy. How to Stand Out, Spread Career Risk and Simplify Your Work Speaker: Stephan Si-Hwan Park (UNCONSCHOOL Online Platform) Leadership Seminar This seminar is held annually for LBI Principals and organized by the LBG Office to facilitate the exchange of experiences and introduce new idea. In addition, processes on specific strategic topics were co-developed as part of the workshops. As a result of the workshop, three specific projects were initiated: At the LBG, professional development mainly takes place at the institute level and is therefore best suited to the particular needs of the respective scientific discipline and its financial situation. Following internal discussions with department heads, the LBG office initiated additional employee development and career planning programs in 2013. In the future, these programs will be established in close coordination with the Director of the Institute by 2018: Principal Investigator Training Additional training for principal investigators should mainly cover the soft skills required for middle management roles (e.g. motivation, conflict management, etc.). Participating LBIs/LBCs identify relevant training topics during the rotation process, research relevant courses (seminars, courses, etc.) and invite colleagues from other LBIs and LBCs to participate. In addition to qualifications to work at the Ludwig Boltzmann Institutes and Clusters and subsequent careers, this should also generate a larger LBI/LBC network at key researcher level, thus enhancing the corporate profile. The program started Other programs already in place: Meet the Experts Meet the Experts The 2010 Young Scientists for Young Scientists series of events was also well attended in 2013. As part of these activities, Young Scientists invite in-house experts to exchange knowledge on certain topics, collect information relevant to their own careers, organize the following events: Applied Human, Social and Cultural Sciences? To what extent can GSK's field be application-oriented and can the two fields be brought together? Lecturer: Jürgen Mittelstraß (Austrian Science Council/Konstanz Science Forum) postdoc What now? Crisis or opportunity? Speakers: Karin Harrasser (Arts University Linz), Rupert Gaderer (Ruhr-Universität Bochum) Strengths and Weaknesses of an Early Scientific Career: Basic Roadmaps for Masters, PhDs and Postdoctoral Success Lecturer: Daniel G. Remick (Boston University School of Medicine) open innovation project application and approval at the National Foundation for Research, Technology and Development, Home By actively engaging various players in the healthcare system, LBG hopes to ask new relevant questions and collectively find innovative answers . With this project, LBG also hopes to further strengthen its focus on health sciences. Intellectual Capital Reporting Working Group A working group comprising the Director of the Institute and the Chief of Staff was formed to identify the indicators that the LBI and LBC will refer to in the Intellectual Capital Statement. Leadership in the Natural Sciences In the same year, the above-mentioned concept for the training of key researchers was developed and implemented. 12 Ludwig Boltzmann Society Ludwig Boltzmann Society 13

8Ludwig Boltzmann Society Career Breaks and Awards Career Breaks Habitations Peter Ruggenthaler, LBC for History, Habilitation in Contemporary History The subject is Stalin's concept of neutrality in foreign policy The Habilitation paper now appears as a monograph in the Harvard Cold War Studies Series at Harvard University. Richard Moriggl, Lukas Kenner of the LBI Cancer Research Center and the crazy cousin of Emilio Casanova-Hevia announced the appointment of professorships at the Medical University of Vienna and the Veterinary University of Vienna. Jochen Hofstätter from LBI Osteology is licensed to teach as a private tutor. Eva Scheurer, director of LBI's Clinical Forensic Imaging Institute, is certified in forensic science with a focus on MR imaging and MR spectroscopy in forensic science. Doctoral dissertation Walter Iber, LBC History, has been a university assistant at the Department of Economic, Social and Business History at the University of Graz since May 2013. Teacher training papers on promoting school health. David Santer of the LBC Cardiovascular Research Center has a residency in Cardiovascular Surgery at Hietzing Hospital following his GP training. Cardiovascular Research LBC's Marcus Granegger received his Ph.D. cum laude with a dissertation on the interaction between the heart and the rotating blood pump: non-invasive monitoring and research in an isolated cardiac environment. Julia Planitzer from LBI for Human Rights successfully completed her thesis on the Council of Europe Convention on Combating Human Trafficking and a human rights-based approach to human trafficking. Pulmonary Vascular Research Nagaraj Chandran, Slaven Crnkovic, and Diana Zabini of LBI received PhDs for their work on the effects of TASK-1 on human pulmonary artery smooth muscle cells Antiproliferative effects of omega-3 fatty acids in human pulmonary artery smooth muscle cells (Crnkovic) and the influence of the microenvironment and the role of cytokines in chronic thromboembolic pulmonary hypertension (CTEPH) (Zabini). Osteology LBI Ines Sturmlechner moved to the Institute of Molecular Biotechnology (IMBA) to write his master's thesis on the mechanistic aspects of the mammalian tRNA ligase HSPC117 under the scientific supervision of its Director Josef Penninger in the group of Javier Martínez. Karin Waldherr from the LBI for Health Promotion Research has transferred to the Ferdinand Porsche Fern-Fachhochschule as Designated Director of the Aging Services Management Course. Ingo Zechner of the LBC History Department has been promoted to Deputy Director of the International Center for Cultural Studies in Vienna. 14 Ludwig Boltzmann Society Ludwig Boltzmann Society 15

9Lukas Kenner, the Ludwig Boltzmann Society's Awards and Honorary Vice-President. Director of Cancer Research at LBI, winner of the 2013 CESAR Excellence Award for Translational Research in Cancer Drug Development at the Annual Meeting of the Central European Society for Cancer Drug Research. Werner Kullich, Senior Key Researcher in Medical Disease Rehabilitation at the LBC Center for Rheumatology, Balneology and Rehabilitation, has received the 2013 Scientific Award for Clinical Pain Research and the first prize for the Research Theme Poster Presentation from the Austrian Pain Society. In MRI of osteoarthritis. Richard Morigl, Director of Cancer Research at LBI, has been awarded the CEIBS Cancer Research Award for outstanding scientific achievement in the development of clinically relevant cancer models. LBI Human Rights Director Manfred Nowak has received the Lisl and Leo Eitinger Human Rights Prize from the University of Oslo. Jan Pencik, LBI for Cancer Research, won first place in the poster prize competition at the first LBG for Health Sciences conference for her paper Loss of IL-6 or Stat3 drives advanced prostate cancer by promoting p53 inactivation. Stefan Stojkovic of the LBC Cardiovascular Research Center won the Best Poster Award at the European Thrombosis Summit of the Thrombosis Working Group of the European Society of Cardiology in Uppsala and the Best 10 Poster Award at the 1st LBG Cardiovascular Science Conference . healthy. Scientific Events 2013 Events organized by the LBG Office and participation in High Potential Days 2013 LBG regularly participates in the annual High Potential Days event in the Vienna City Hall, which enables graduates of universities and technical schools to find out about interesting employers / Extensive information on insiders, networking and invitations to on-site interviews. On High Potential Day, June 25, 2013, three LBI/LBCs invited job interviews as part of the LBG: LBI for Cancer Research, LBI for Health Promotion Research and LBC Oncology. LBG Weinherbst As the start of the science-politics autumn, the LBG Chairman invited people to the first LBG Weinherbst on October 8, 2013 on the 20th floor of the new Raiffeisenhaus in the center of Vienna. Impressive panoramas form the backdrop for exciting gatherings of the scientific and research community. Daughters of LBG President DI Josef Proell and Minister of Science and Research O. Univ.-Prof. Dr. Karlheinz greeted the many guests present. Research Clubs: Biotech, Clinical, Public Health: What research do we need for our health? Club Research is a series of scientific, research and innovation events organized monthly. Regarding its new research focus in the health sciences, the LBG office organized a research club on October 30, 2013 on the topic Biotechnology, Clinical, Public Health: What Research Does Our Health Need? Guests on the podium were Dr. Claudia Wild, Head of Health Technology Assessment at LBI, Dr. Wolfgang Dür, Director of Health Promotion Research at LBI and PD DDr. Georg Bauer, University of Zurich and ETH Zurich Researcher in Health and Work, Ph.D. Thomas Czypionka, Head of Health Economics and Health Policy, IHS, Prof. Ph.D. Hellmut Samonigg, Head of the Clinical Department of Oncology at the Medical University of Graz. BIO-Europe Vienna 4-6 November 2013 For the second time in four years, BIO-Europe, Europe's largest trade fair for biotechnology partners, took place in Vienna. Academic institutions also have the opportunity to present their research there for the first time. The LBG Office took the opportunity to present some of its projects in the field of biotechnology. 1st LBG Health Science Conference On December 2, 2013, the LBG Office with its Institutes and Clusters in the field of Medicine/Life Sciences organized the 1st LBG Health Science Conference in Casa de la Industria. The conference is a prelude to several LBG events as part of its new strategic focus in the health sciences. The purpose of the meeting was to give each other a better understanding of the research activities of the LBG Institute and the Cluster, with a focus on medical research and public health. The program includes lectures and poster presentations, in which young scientists from the LBG are purposely placed in the foreground. The event culminated with the award ceremony for the three best scientific posters 16 Ludwig Boltzmann Society Ludwig Boltzmann Society 17

10Events and participation organized by Ludwig Boltzmann Gesellschaft LBI/LBC LBI Archaeological Exploration and Virtual Archaeology 10th International Conference on Archaeological Exploration From 29 May to 2 June 2013, an international conference on the topic of archaeological exploration was held in Vienna. The conference is organized by LBI Archaeological Prospecting and Virtual Archaeology (LBI ArchPro). On the eve of the congress, LBI ArchPro's latest findings were presented at a press conference in Wiener Neustadt. This involved the discovery of the Viking headquarters in Borre/Norway, which was made possible through strong international cooperation and good partnerships with measurement technology companies such as remote sensing via airborne laser scanning. LBC History / LBI Consequences of War Research LBI Consequences of War Research 20th Anniversary On 7 June 2013, LBI Consequences of War Research (BIK) celebrated its 20th anniversary with a discussion and ceremony at Prof. Dr. Stefan Karner. LBG's Board of Directors is represented by mag. Christopher Neumeier. LBI Human Rights Vienna World Conference on Human Rights 20th Anniversary 2013 also marked the 20th anniversary of the Vienna World Conference on Human Rights, overseen at the time by the newly established Ludwig Boltzmann Institute for Human Rights. On this occasion, on 27-28 June 2013, the Expert Meeting Vienna+20 Advancing Human Rights Protection was held at the Vienna Office of the United Nations High Commissioner for Human Rights. Building on the outcomes of the World Conference, leading experts from around the world discussed how to further strengthen the international human rights system. 15th European Shock Society (ESS) Congress of LBI Experimental and Clinical Traumatology + 9th Vienna Shock Talks LBI of Experimental and Clinical Trauma (LBI Trauma) 12-14 jointly held the 15th European Shock Congress held in Vienna General Hospital in September 2013 "Vienna Shock Talks". At the heart of the congress is the treatment of sepsis and personalized medicine. International Automobile/Biographical Association (IABA) European Conference on LBI History and Theory in Vienna From 31 October to 3 November 2013, LBI History and Biographical Theory (LBI GTB) hosted the International Automobile/Biographical Association (IABA) Association Conference ( association). IABA) Europe. IABA is the largest international association of biographers and autobiographers, with members and chapters in China and Hawaii. LBI GTB Director Prof. Mag. Wilhelm Hemecker is one of the founders of IABA and IABA Europe. LBC Cardiovascular Research Lecture in Vienna: Obesity is a widespread disease On 18 November 2013, Johann Wojta, coordinator of LBC Cardiovascular Research (LBC Cardio), gave a lecture on "Adipocytes: Beauty or something else?" . Lectures on the topic of obesity as a pervasive disease. Other events in 2013 (selected): Human Rights Lectures LBI Human Rights Event Series 32. Advanced Training Conference in Rheumatology LBC Interdisciplinary World of Forensic Imaging in Rheumatology, Balneology and Rehabilitation LBI Clinical Imaging Conference Series Forensic Kickoff Events Styria CSI Network Forensic Clinic Austria? Austrian Health Promotion Hospitals and Health Facilities Network Clinical Forensic Imaging Conference hosted by LBI and 21st International Conference on Health Promotion Hospitals and Health Services (co)Health Promotion Research Information Event hosted by LBI Baby Friendly Hospital Initiative LBI for Health Promotion Research Erstes Patient / Graz Internal meeting for patients with pulmonary hypertension and their relatives Pulmonary Vascular Research LBI International Symposium on Myeloproliferative Neoplasms LBC Oncology Conference Crossing Mountains and Chargers as an Achievement LBI Public Relations for New Latin Research Raising Research Awareness and Among the Population Scientifically, the findings are presented in a manner that is understandable to the majority of the treated population. For this purpose, a corresponding information event was used, but also classic PR tools were used, the LBG office issued numerous press releases about the ongoing research work of its institutes and clusters and organized two press conferences and a press talk . .In addition to working with the media, LBG's website was relaunched and a promotional event was held. Internal Communications In order to digitize certain administrative processes and facilitate the exchange of information between the individual LBIs/LBCs and offices, an Intranet was launched for all LBGs in summer 2013. In addition, in-house seminars and events are held. Facilitating communication within LBG again and again. Participation in new funding platform LBG Since 2013 there have been projects from five LBIs and one LBC on the InjectPower platform. Inject-Power is Austria's first online portal for private research funding. There, any website visitor can learn about selected scientific projects and support this research with a donation. Ludwig Boltzmann Society Ludwig Boltzmann Society 19

11Ludwig Boltzmann Institute and Clusters

12Ludwig Boltzmann Institute of Archeology and Institute for Virtual Archaeology Austrian high-tech LBI ArchPro multi-antenna ground radar system for snow surveying, developed especially for Borre (Photo: LBI ArchPro, Erich Nau) Research and Virtual Archeology at Ludwig Boltzmann Institute for Archaeology Archaeologists (LBI ArchPro) are archaeologists, geophysicists, geodesists, computer scientists, physicists, geologists, remote sensing experts and technicians who develop effective surveying techniques and methods to detect , documenting and visualizing the hidden cultural heritage of destruction in the air and on the ground across landscape spaces on Earth. The development of new technologies and approaches is tested and optimized in close cooperation with LBI-ArchPro partner organizations and partner institutions and companies based on selected large-scale case studies in partner countries. The above-average positive assessment of the Institute by an international team of experts in November was recorded by LBI ArchPro as a resounding success and a clear confirmation of the previous research program and its results. The survey continued to be successful in 2013. Given the wealth of archaeological information in the 32 km² area investigated so far, the main focus in 2013 was the evaluation of the survey data. Specialized computer tools for comprehensive interpretation of archaeological structures in dynamic 4D archaeological GIS can be further developed and improved through close cooperation between archaeologists, geodesists, and computer scientists. In southern Norway, mapping of important Viking Age sites in the archaeological landscape around Gokstad, Oseberg and Borre has been declared a UNESCO World Heritage Site for the third year in a row, revealing settlement patterns to date. In February 2013, a uniquely constructed chieftain's seat was discovered in Borre and presented to the international press, using a new ground-based radar system developed for use in snow-covered regions in winter. As part of the Birka-Hovgården (S) case study, the main remaining area of ​​Björkö island was surveyed manually using radar, while a larger area of ​​neighboring Adelsö island was surveyed for archaeological traces using mobile systems. At the invitation of the Swedish Antiquities Administration, LBI-ArchPro plans to start contributing the latest research results to the archaeological exhibition at the Birka Museum for the first time in May 2014. The translational and interdisciplinary nature of LBI ArchPro research is reflected in the following project: Germany and Abroad 2013: Important Insights into the Construction of Frederick III's Mausoleum at St. Stephen's Cathedral in Vienna. Habsburg ( ) worked with LBI CFI to use ground penetrating radar, terrestrial laser scanner surveys and endoscopy. In Santorini (GR), a project funded in partnership with the National Geographic Society Conservation Trust has digitally documented the Bronze Age settlement of Akrotiri through extensive laser scanner measurements and extensive photogrammetric imagery, This enabled a virtual and archaeological reconstruction of this important cultural monument. Research results were presented at several international conferences in 2013. In May 2013, LBI ArchPro together with OeAW organized the 10th International Conference on Archaeological Exploration (AP2013) in Vienna. Around 250 participants from all over the world, including recognized experts from the fields of geophysics, archaeology and informatics, experienced archaeologists and young researchers, as well as students, gained access to the latest research in the field of archaeological investigation of monuments and monuments and applied impressive information on archaeological sites in more than 160 presentations. Virtual lecture by archaeological exploration pioneer Irwin Scollar during the opening of the AP2013 conference (Photo: LBI ArchPro, Geert Verhoeven) 1. Doneus, M. (2013): Heritage Landscape Exploration and Interpretation in Landscape Archeology. Vienna: Verl. Austrian. Acad.d. knows (Communications from the Council on Prehistory, 78). 2. Doneus, M.; Doneus, N. Brees, C.; Pregesbauer, M.; Mandelberg, G.; Verhoeven, G. (2013): Airborne laser bathymetry: detecting and recording underwater archaeological sites from the air. In: Journal of Archaeological Science (40), S DOI:/j.jas Doneus, M.; Gugel, C.; Doneus, N. (2013): Canabae of Carnuntum, a model for the outskirts of the Roman camp? From exploration of aerial photographs to synthesis of archaeological settlements: Verlag OAW (Austrian Roman lime, 47). 4. Neubauer, W. Trinks, I.; Salisbury, R.B.; Einwögerer, C. (eds.) (2013): Archaeological exploration. Proceedings of the Tenth International Conference on Archaeological Exploration. Vienna, Austria, Vienna: Verl. Acad.d. Know 5. Saey, T.; van Meirvenne, M.; Desmet, P. Neubauer, W. Trinks, I.; Verhoeven, G.; Seren, S. (2013): Integrating multi-receiver electromagnetic induction measurements into the interpretation of the soil landscape surrounding the gladiator school in Carnuntum. In: European Soil Science Magazine (64), S Ludwig Boltzmann Institute for Archaeological Prospecting and Virtual Archaeology Hohe Warte 38, 1190 Wien Administration@ArchPro. 22 Ludwig Boltzmann Institute lbi Archaeological Prospecting and Virtual Archaeology 23 PD leader oh. University Professor Mag. Dr. Wolfgang Neubauer Associate Director Univ.-Prof. Mag. Dr. Michael Doneus Principal investigator: 3 PhD students: 12 Scientific staff: 21 Administrative staff: 4 Assistants: 2 Airborne Technology (AT) Vienna University of Technology (AT) NIKU (N) Riksantikvarieämbetet UV Technik ( RAÄ ) ( S) Central Roman-Germanic Museum Mainz RGZM (D) Center for Visual and Space Technology VISTA, University of Birmingham (GB) Lower Austria State Office (AT) Vestfold Fylkeskommune (NO) Central Meteorology and ZAMG Earth Institute of Dynamics (AT) ) COMMITTEES Scientific Advisory Board Professor Kay Kohlmeyer Berlin University of Applied Sciences (HTW) (D) Prof. Julian Richards University of York (GB) Professor Joakim Goldhahn Linnaeus University (S) Professor Maurizio Forte Duke University, Professor, Durham, NC (USA). Sarah Parcak University Alabama (USA) Watch a video about the Institute

13Ludwig Boltzmann Institute COPD and Lung Epidemiology THE LEAD STUDY, the largest lung health study in Austria, recruiting subjects from Vienna and Lower Austria Lung Health Study (LEAD Study) until the end of 2013, Ludwig Boltzmann Institute for COPD Boltz and Epidemiology Pulmon Boltz (Ludwig Boltzmann COPD Boltz Institute) Topic investigated during the LEAD study. In addition, the number of test subjects recruited per day increased from 12 to 15 a day to meet the scheduled completion of the first phase on time. Furthermore, as part of the LEAD study, a contractual partnership was signed with the Lower Austrian Health Community using the Lower Austria state logo and the communities of Mauerbach and Leobersdorf were recruited as rural areas for the LEAD study. In addition, LBI COPD signed a contract with the Danish Environmental Protection Agency in Vienna, which gave LBI COPD the opportunity to transmit air quality data for NOX, PM10, PM2.5 and ozone where the test subjects live. Must be scientifically investigated and used. Finally, the LEAD study became a partner of the Accelerate Consortium, which is applying for an EU grant (Horizon 2020) to address COPD and asthma weakness. The Bronchoscopic Lung Volume Reduction COPD Interventional Task Force has completed and published several major projects. In this regard, reference is made to the work of Valipur et al. (ERJ 2013), who identified clinical predictors of response to valve therapy in emphysema. Moreover, the expansion of indications for endoscopic valve implantation, viz. Treatment of extended bronchopleural fistulas, defined and systematically tested in clinical studies (Firlinger et al, Ann Thorac Surg 2013). The increasing experience of endoscopic treatment of COPD has also been confirmed by prospective studies conducted within the framework of national and international collaborations with LBI COPD as the main research center (Principal Investigator: A. Valipour). COPD and Intensive Care The presence of COPD has been identified as an independent risk factor for increased morbidity and mortality in critically ill patients in the intensive care unit. Several other publications describe aspects of sodium and water balance in severe acute illness. Finally, the value of the biomarkers hs-troponin T and D-dimer in renal failure was rigorously investigated. Ph.D. (Doctor of Philosophy) As declared, Ph.D. Mary Breyer for her Ph.D. at Maastricht University. During his PhD, he published seven articles in peer-reviewed journals and published his scientific work on COPD and obesity in book form. LBI COPD and Pulmonary Epidemiology Team 1. Valipour A, Herth FJ, Burghuber OC, Criner G, Vergnon JM, Goldin J, Sciurba F, Ernst A; Waiting Study Group. Measuring lobe volume reduction and COPD outcomes after endobronchial valve therapy. Eur Respir J Epub Jul 2013 Firlinger I, Stubenberger E, Müller MR, Burghuber OC, Valipour A. Endoscopic one-way valve implantation and use of digital air leak monitoring in patients with chronic air leaks. Ann Thorac Surg Apr;95(4): Funk GC, Bauer P, Burghuber OC, Fazekas A, Hartl S, Hochrieser H, Schmutz R, Metnitz P. Prevalence and prognosis of COPD in critically ill patients between 1998 and April Eur Respir J ;41(4): Fazekas AS, Funk GC, Klobassa DS, Rüther H, Ziegler I, Zander R, Semmelrock HJ. Evaluation of 36 formulas for calculating plasma osmolarity. Intensive Care Med Feb;39(2): Roberts CM, Lopez-Campos LJ, Pozoi-Rodriguez F, Hartl S; European Audit Team. Adherence to the GOLD recommendations for admissions due to exacerbation of chronic obstructive pulmonary disease (COPD) in European hospitals. Thorax 2013 Dec;68(12): Ludwig Boltzmann Institute of COPD and Pulmonary Epidemiology LEAD Study Center Otto-Wagner-Spital/G-Building Sanatoriumstrasse 2, 1140 Wien Head Prim. University - Prof. Dr. Oätto C. Burghuber Deputy Director OÄ en Dr. en Sylvia Hartl Head of Academic Society: 2 Doctoral Students: 5 Academic Staff: 10 Administrative Staff: 2 Federal Ministry of Health (AT) Vienna Hospital Association ( AT) City of Vienna (AT) Lower Austria (AT) Medical University Vienna (AT) Filmseinstituttet 24 Ludwig Boltzmann Institute LBI COPD and Pulmonary Epidemiology 25

14Ludwig Boltzmann Electrical Stimulation and Physical Rehabilitation in Aging Mobility and Clinical Patient/Internal Orientation in Cancer Patients Reg. A. Barton, former Regional Manager, in his introductory presentation on Aging Causes Progressive Muscle Loss (sarcopenia), slowed movement, and decreased muscle strength. The result is uncertainty and difficulty coping with everyday activities. Mobility in the Elderly is a research project within the EU-Slovakia-Austria Cross-Border Cooperation Program in cooperation with the Faculty of Physical Education of the Comenius University in Bratislava and the Center for Medical Physics and Biomedical Engineering of the Medical University of Bratislava Vienna. The main goals of the Elderly Active Program are research and treatment of age-related muscle changes (functional, histological, electron microscopy and molecular biology), development of new training methods to restore muscle function in older adults, and networking among researchers . In Vienna and Bratislava. The peak in 2013 occurred in October. The Ludwig Boltzmann Institute for Electrostimulation and Physical Rehabilitation (LBI Electrostimulation) organized an event for test subjects, partners and sponsors as well as political representatives of the EU Mobility in the Elderly Project (ETZ SLOVAKIA-AUSTRIA programme). The purpose of the event is to present the first results of the study. The technical development of the training device and the functional results of the training set are presented, along with findings from histology, molecular biology, and electron microscopy. Subjects could then share their personal experiences directly with the scientists present. University Professor H. Kern, Head of Electrical Stimulation at LBI East Germany, thanked test subject H. Reiter for his participation. Three publications resulting from the project were accepted by recognized journals and will be published in 2014. An extension of the project was approved until the end of 2014, allowing LBI Elektrostimulation to fully evaluate and adapt the study protocol to include patients with breast and prostate cancer. Prospects The Institute's activities in 2014 will focus on the inclusion of cancer patients in the ongoing EU Elderly Mobility project. The main task will be the implementation of clinical studies. Two new project applications for participation in the 2015 Horizon 2020 program and the ETC SLOVAKIA-AUSTRIA program are in preparation. 1. Electrical stimulation prevents age-related muscle atrophy in humans. H Kern, S Loefler, S Burggraf, H Fruhmann, J Cvecka, M Sedliak, L Barberi, M De Rossi, A Musarò, U Carraro, S Mosole, Sandra Zampieri. Eur J in Trans Myol. 2013;23(3): Evidence-based medicine in physical medicine and general rehabilitation. H Kern, S Loefler, V Fialka-Moser, T Paternostro-Sluga, R Crevenna, S Burggraf, H Fruhmann, C Hofer, C Burmester, EM Strasser, M Praschak, W Grestenberger, Fh Hartl, GE Ebenbichler, G Wiesinger, T Bochdansky, C Wiederer, Ml Quittan. Eur J in Trans Myol. 2013;23(4): Monitoring compliance with home electrical stimulation training in older adults. Hendling M, Krenn M, Haller MA, Loefler S, Kern H, Mayr W. Biomed Tech (Berl) Sep Effects of visual removal during a different foot position stopping task. Sarabon N, Rosker J, Loefler S, Kern H. Gait posture Sep;38(4): Improvement of spasticity in patients with incomplete spinal cord injury by percutaneous spinal cord stimulation. Hofstoetter US, McKay WB, Tansey KE, Mayr W, Kern H, Minassian K J Spinal Cord Med June 12. [Advance electronic publication] Ludwig Boltzmann Institute for Electrostimulation and Physical Rehabilitation Montrealartstraße 37, 1160 Wien Head University Professor East Germany Helmut Kern DI Deputy Director Stefan Löfler DI Dr. Christian Hofer Principal investigators: 4 PhD students : 2 diploma students: 2 undergraduate students: 2 scientific experts: 2 Wiener Krankenanstaltenverbund (AT) Watch a film about the Institute 26 Ludwig Boltzmann Institute LBI Electrostimulation and Physical Rehabilitation 27

15Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Translational research from the beginning... The shock and sepsis research area of ​​the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma) focuses on personalized medicine. An important focus is the monitoring of accident and intensive care patients, especially by plasma parameters. An analytical device is currently being developed (FFG BRIDGE project) to record sepsis and inflammation parameters directly at the bedside. Using thromboelastography/measurement (ROTEM), the coagulation status of accident patients can be determined in the shock room; new/improved methods have been developed for this purpose. As part of these experiments, endothelial cells were also introduced for the first time into a viscoelastic test system and their effect on the coagulation properties of whole blood was studied (patent). Clot containing microspheres of endothelial cells and sepsis and their therapeutic implications in the analysis of whole blood coagulation using ROTEM. A highlight was the organization of the 15th Congress of the European Shock Society (chaired by Prof. Soheyl Bahrami), where researchers from 14 countries on four continents could exchange their latest findings in the field of shock and sepsis. The best young researchers were awarded. Winners Winners ESS Vienna 2013 In the field of tissue regeneration, the 16th International Shockwave Congress in Salzburg with Dr. Rainer Mittermayr (President) and Wolfgang Schaden in Salzburg. Extracorporeal shock waves can significantly accelerate chronic wound healing in the clinic (Koop. UKH Meidling). Increased VEGF formation (vascular endothelial growth factor) could be tested as a possible part of the mechanism of action. Other studies have investigated the response of cells to mechanical stimuli that release ATP (mechanotransduction) (collaboration between FH Technikum Wien and Harvard University). Shockwaves can also significantly improve peripheral nerve regeneration by dramatically accelerating the growth of nerve axons. The reason may be the impact of the shock wave on the Schwann cells. So those are the focus of the investigation. The latter showed that the shock wave had a strong effect on Schwann cells in the form of improved isolation and activation. A similar effect was seen with Schwann cell-like cells made from fat stem cells. Last year, an international consortium working with LBI Trauma published appropriate guidelines for isolating adipose-derived stem cells. For these cells, an SOP for the production of GMP for patients is being prepared together with collaborator Blutzentrale Linz, another example of a translational approach. Stem cells often require a matrix in which they can grow well. Can be used with silk fibroin and has shown good results in preclinical trials (patent registered). One of the main priority projects in 2013 (the development of a new hemostatic material at FFG headquarters) was carried out in cooperation with a major industrial partner, but had to be put on hold as the partner had almost completely stopped research in this area. Ongoing EU biodesign projects (prevascularization, stem cell differentiation, reporter systems and bioreactors) are progressing well, especially with regard to new collaborations in muscle regeneration and cardiomyocytes. The new EU project IMCOSS (Bone Therapy Using Nanoparticles) is off to a good start. The UGEN project on the transfection of active cells has been completed, and a new combination of bone growth factors (BMP2/7) can be used in non-viral gene therapy (sonoporation). Representative Results: µct 56 Days Control Treatment Bone Regeneration Using Nonviral Ultrasound-Assisted Gene Therapy 1. Complete differentiation of the human placenta to the Schwann cell lineage. Banerjee A, Nürnberger S, Hennerbichler S, Riedl S, Schuh CM, Hacobian A, Teuschl A, Eibl J, Redl H, Wolbank S. Tissue Bank Oct 29. [Epub ahead of print] 2. Remove sericin from Bombyx raw mori high-grade silk holder. Teuschl AH, van Griensven M, Redl H. Methods in tissue engineering part C, 25 September. [Electronic version before publication] 3. Experimental data show that inflammation-mediated mitochondrial dysfunction in rat liver is caused by secondary hypoxia, rather than the direct effect of inflammatory mediators. Weidinger A, Dungel P, Perlinger M, Singer K, Ghebes C, Duvigneau JC, Müllebner A, Schäfer U, Redl H, Kozlov AV. Front Physiol Jun 7;4: Maximum thromboelastographic clot stiffness in platelet-free plasma is affected by the assay used. Schlimp CJ, Solomon C, Hochleitner G, Zipperle J, Redl H, Schöchl H. Anesth Analg Jul;117(1):23-9. Epub 3 June 2013. Ludwig Boltzmann Institute for Clinical and Experimental Traumatology Donaueschingenstraße 13, 1200 Wien Head Univ.-Prof. Dr. Heinz Redl Univ.-Doz. Dr. Albert Kröpfl Associate Director Univ.-Prof. Di Dr. Soheyl Bahrami Principal Investigators: 10 Postdocs: 3 Doctoral Students: 24 Graduate Students: 13 Master Students: 3 Undergraduate Students: 1 Scientific Staff: 61 Other Scientific Staff: 2 Administrative Staff: 5 Assistant: 2 Allgemeine Unfallversicherungsanstalt (AT) See Institute Movie 5 . Platelet-derived growth factor AB bound to fibrin biomatrix accelerates wound healing in severely thermally injured wounds. Mittermayr R, Branski L, Moritz M, Jeschke MG, Herndon DN, Traber D, Schense J, Gampfer J, Goppelt A, Redl H J. Tissue Eng Regen Med May 31. [Electronic ahead of print] 28 Ludwig Boltzmann Institute LBI Experimental and Clinical Traumatology 29

sixteenNew Forms of Biographical Narrative at the Ludwig Boltzmann Institute for History and Biographical Theory. The FWF-funded Mira Lobe Project on Virtual Life, Science and Cultural Writing has successfully completed, which for the first time examined her entire body of work by genre, theme and theme, including her legacy. As a next step, LBI GTB will be involved in organizing a major exhibition on Mira Lobe and Susi Weigel, which is planned for autumn 2014 at the Vienna Museum. Additionally, the paper contains the results of a project called Mira Lobe. Dean of Austrian Children's and Youth Literature. A biography of the poet in the traditional linear chronological order, but recounting Hofmannsthal's life from the places and scenes that were decisive for his biography. Work continued in 2014 on the Handbook of Young Vienna Biography and a complete volume on Young Vienna Biography and various cultural and scientific topics will be published by the renowned academic publisher de Gruyter in 2016. The online biographies of Ernst Jandl and Karl Kraus as well as the online project Biographeme are also continuing in the virtual biography project. Biographeme is a collaborative platform for the development of innovative biographical representations based on social networks. The possibilities for understanding and presenting biography expand with interactivity and open up new perspectives in this field of study. Ludwig Boltzmann Institute for Biography History and Theory Porzellangasse 4/1/17, 1090 Vienna Director Univ.-Prof. Dr. Wilhelm Hemecker Associate Director Dr. Tobias Heinrich PostDoc: 3 PhD students: 6 undergraduate students: 1 administrator: 1 other contractor: 1 Ludwig Boltzmann Institute for Biographical History and Theory (LBI GTB) in cooperation with University of Vienna organizes The International Auto/Biographical Association (IABA) European Conference 3-3 October 2013 November. With more than 1,000 members, the IABA is the world's largest association of biographers and researchers in the field of biographical history and theory. Conference theme, Beyond the subject. New developments in life writing, with a particular focus on the importance of new media to (automated) biographical storytelling. Among the 150 attendees were internationally renowned lifestyle writing experts who spoke about the latest trends and developments in the digital humanities. Therefore, this meeting is fully relevant to the Institute's research projects, especially the virtual biography project. A project was launched on October 1, 2013, funded by FWF, dedicated to the most important turning point in the life of Oskar Pastior. The focus is on the often talked about relationship between working life and its public acceptance. At the end of the three-year program there will be full scientific publications. Perspectives Two conferences organized by the LBI GTB will take place in 2014: The link between the Viennese Art Nouveau tradition and the biographical handbook of young Vienna. Experts will publicly present new insights into how young Vienna deals with modernity and anti-modernity. The topic of the second lecture is the charm of communism. It will also take place in Vienna and will focus on exposing the flaws in the biography of communism and other ideologies. The outcome of this meeting is an integral part of the construction of new programmatic themes. In this context there is also the study of Arthur Koestler, whose life, work and reception will be published in a publication based on a metabiographical approach. That same year, a workshop on "Biography of the Flux Era" was held in collaboration with UC Berkeley. The results of the three sessions will be published in the conference proceedings. In autumn 2014, Zsolnay & Deuticke launched the band Hofmannsthal. place. 24 biographical constellations that bring to life the first stage outline. 1. Katharina Prager: If I could go to Europe, the war would be over in a minute. Reader Karl Krauss in World War I. In: Alfred Pfoser and Andreas Weigl (eds.): At the epicenter of the collapse. Vienna in World War I. Vienna: Metro 2013, S Roman Hutter: We belong to Europe Interview with Valeriu Chiveri, Ambassador of the Republic of Moldova. In: Country Handbook for the Republic of Moldova. IDM Special Issue 1/2013, S Tobias Heinrich: Biography as Translation: From Biographical Genealogy to Contemporary Connections. Results of the Doctoral Symposium in German Studies in Vienna. edit. Peter Clar, Markus Greulich, Birgit Springsits. Vienna: Praesens 2013, Georg Huemer: Mira Lobe, Dean of Methods of Life and Work in Austrian Children's and Youth Literature. In: Contemporary Links. Results of the Doctoral Symposium in German Studies in Vienna. edit. Peter Clar, Markus Greulich, Birgit Springsits. Vienna: Praesens 2013, S Ed Saunders: (Russian translation) Snimki vymyshlennykh kartin, translation by Olga Gerasimovich. Exhibition text by Norbert Wiesneth: Königsberg-Kaliningrad Kunsthalle-Avtodom, Russian National Center for Contemporary Art Baltic Branch, Kaliningrad, Russia, August Austrian National Library (AT) University of Vienna (AT) Bixa TechnoConsulting (AT) Vienna City Library Museum (AT) 30 Ludwig Boltzmann Institute LBI History and Theory of Biography 31 COMMITTEE Scientific Advisory Council Univ.-Prof. Dr. Peter-André Alt University Professor, Free University of Berlin (DE). en dr en Ute Frevert Max Planck Institute for Human Development, Professor at the University of Berlin (Germany). Alfred Hornung Johannes Gutenberg University, Professor at the University of Mainz (Germany). Dr. Gerhard Lauer University Professor at the University of Göttingen (Germany). Dr. Hans Renders University of Groningen (Netherlands) Watch a video about the Faculty

17Health Promotion Interventions in Schools, Hospitals and Elderly LBI Health Promotion Research Team Ludwig Boltzmann Institute Health Promotion Research The Ludwig Boltzmann Institute for Health Promotion Research (LBI HPR) Setting Comparison Line Program compared three organizational settings (schools, hospitals, long-term care) Question, How Health Promotion Interventions Can Be Successfully Implemented in Expert Organizations. The study examined evidence-based interventions in all three settings. Data collection took place in summer 2013 and individual analyzes were largely completed by the end of 2013 so that comparative analyzes could begin. The preliminary results are that, on the one hand, similarities and differences between the three scenarios are observed. For example, hospitals and some nursing homes have effectively implemented health promotion programs through their own structures, but schools have limited resources and capacity. The final report will be published in March 2014. LBI HPR's Health Promoting Schools (HPS) program stream focuses on mental health and health inequities. HPS hosted the Mental Health Dialogue in Healthy Schools and published a research report on school climate, a meta-review and fact sheet on the impact of health promotion in schools (Healthy Behaviors in School-Aged Children). The scientific findings underscore the current priorities of the Austrian Child and Adolescent Health Strategy and the National Mental Health Strategy of the practice partners. Our work on health inequalities (research reports, scientific articles) recommends critically examining each health policy measure in terms of its inequality-related impact. The line of health-promoting long-term care projects follows the results of the hospital facility Health for All Ages pilot project, which was transitioned to routine operation in 2013. The scientific monitoring of the LBI HPR focuses on three areas: 1. Employee health, through which the issues of the implementation of the ergonomics pilot program were investigated; 2. A measure to facilitate the mobility of residents, in which the sustainability of the effects achieved by the pilot project was examined. 3. Examining the pervasiveness of health promotion in commercial policy for senior housing around the world. In order to transfer the knowledge from the pilot project to other federal states, LBI HPR developed and tested an instrument for rapid diagnosis in aged care facilities. The Routes to Healthy Hospitals program investigates Austria's goal of increasing the proportion of baby-friendly hospitals, ie hospitals that pay special attention to mother-friendly birthing conditions and the promotion of breastfeeding. LBI HPR found that 25% of hospitals were baby friendly and increased deliveries. The evaluation also showed that fundraising strategies involving progressive participation of organizations are suitable for scaling up programs such as baby-friendly hospitals. A simplified form of the 15-year-old European questionnaire was validated in the final report of the Austrian Youth Health Competence Study. One of the results is that the health literacy of Austrian youth is as weak as that of adults. Furthermore, comparative studies of adult health literacy between federal states have found significant differences among them. The Method Center provides advice and quality control for the four project lines mentioned above and conducts its own projects. The evaluation of the Healthy Austria Fund training program helps to create systematic learning for further impact-oriented development of funding practice. The epidemiologically oriented Austrian Adolescent Mental Health Study investigates the mental health of children and young people in Austria. The first phase of data collection using a validated screening questionnaire consisted of approx. Chinese health delegation visits LBI HPR 1. Dür, W. (2013): Application of organizational change systems theory to school health promotion. In: Samdal, O., Rowling, L. (eds.), Implementing Health-Promoting Schools. Explore theories about what, why and how (pp. 34-50). London: Routledge Taylor & Francis Group. 2. Flaschberger, E., Gugglberger, L., Dietscher, C. (2013): Online learning: Individual teacher learning and organizational development in a regional network of health-promoting schools. Health Education Research, 28 (6), Gugglberger, L., Adamowitsch, M., Teutsch, F., Felder-Puig, R., Dür, W. (2013): The use of group discussions: Learning from case study of school organization features. Advanced interview published in: International Journal of Social Research Methodology. 4. M. Nitsch, K. Waldherr, E. Denk, U. Griebler, B. Marent, R. Forster. (2013): Participatory evaluation involving different stakeholders in health promotion: A literature review. Program Evaluation and Planning, 2013 (40), Röthlin,F., Schmied,H., Dietscher,C. (2013): Organizational capacity for health promotion implementation: Results of an international hospital survey. Published in Early Access at: Health Promotion International. Ludwig Boltzmann Institute for Health Promotion Untere Donaustraße 47, 1020 Wien Head Priv.-Doz. mag. Dr. Wolfgang Dür Deputy Director Mag. To Rahel Kahlert, Ph.D., M.P.Aff. Main researchers: 4 postdoctoral students: 16 doctoral students: 11 diploma students: 13 master students: 8 undergraduate students: 1 natural science student. Experts: 4 Administrative staff: 1 Assistant: 2 Federal Ministry of Education, Arts and Culture (AT) Federal Ministry of Health (AT) Health Austria GmbH Foundation for a Healthy Austria (AT) Main Association of Austrian Social Security Institutions (AT) Vienna Health Promotion Non-Profit GmbH WiG (AT) Bielefeld University (DE) St. Louis University Andrews (UK) University of Vienna (AT) COMMITTEE Scientific Advisory Board Em. University Professor East Germany R. Horst Noack, Professor of the Medical University of Graz (AT) Dr. Margaret-Barrie University. Dr Christophsbad Göppingen (DE) Prof. Morris Mittmark University from PD Dr. Günther Bergmann University Clinic, Galway (IE), Ireland. Prof. de Bergen (NO) A Ph.D. en Venka Simovska Aarhus University (DK) Watch a video about the Institute 32 Ludwig Boltzmann Institute LBI Health Promotion Research 33

18Ludwig Boltzmann Institute for Health Technology Assessment Extended to 2020, Funding Changes The first approval and funding period of the Ludwig Boltzmann Institute for Health Technology Assessment (LBI HTA) ended in February, with less and greater involvement from the Ludwig Boltzmann Gesellschaft (LBG) Participation With the participation of the three system partners (HVB/Austrian main social insurance association, BMG/Federal Ministry of Health, 9 federal states/health funds), the LBI HTA has now been extended until 2020. The research institute status and academic research status of the Ludwig Boltzmann Society are retained. In the second period, the funding ratio has now changed significantly: 40 : 25 : 25 : 10 (LBG : HVB : Länder : BMG). So the new thing is that on the one hand the funding is wider (all the federal states instead of the two hospital companies BMG and HVB have the largest share) and on the other hand LBG still has the largest share. , but he took the first step to retire. From 2020, financing must be provided by another provider. In recent years, the LBI MTA has developed several priorities in terms of content and methodology, which are also internationally recognized: For BHV, complex interventions (defined by a range of interventions delivered by different providers) have been mainly assessed in recent years. Year. years and most developed methods: measurement of rehabilitation outcomes, occupational therapy, physical therapy. In a multi-year project, the basis for the repositioning of the Mother-Child Passport to BMG was laid by collecting the disease burden (epidemiology) of new disease risks on the one hand and evidence on preventive interventions on the other. The expensive technical evaluation work area is characterized by early evaluation of new oncology drugs and annual evaluation of MEL/personal medical services to maintain the hospital service catalog. The MTV approach is constantly changing within the LBI MTA as well as internationally. In recent years, the timing of assessment has moved forward (early assessment: shortly before or shortly after approval/market access) but also backward (application follow-up, which includes distributing conditional reimbursements to applicants while generating tests on a daily basis) ). The reason for this is the enormous dynamism of the pharmaceutical and medical device market with constant new product launches. Traditional assessments often quickly become obsolete. The promise of clinical research has not reached everyday clinical practice. Furthermore, due to the increasing cooperation in HTA in Europe, there is a need for English as a working language or at least bilingual work. In the 2012 LBI MTA, 30% of the reports had been written in English. The LBI HTA team is looking forward to welcoming next semester under new conditions! LBI Health Technology Assessment Team 1st Floor B (2013): Public Health: Are We There yet? J Public Health. 21(6): Wild C, Patera N, (2013): Measuring the quality of cancer care: seven country initiatives. European Journal of Cancer Nursing 22 (6): Winkler R, Warmuth M, Floor B, Zechmeister-Koss I (2013): Reorienting the Austrian Parent and Child Preventive Care Program, J Public Health. 21(6): Zechmeister-Koss I, Building B (2013): Affordability of a spontaneous preterm birth prevention program in Austria: A budgetary impact analysis. Eur J Public Health Mar 11. Ludwig Boltzmann Institute for Health Technology Assessment Garnisongasse 7/20, 1090 Wien Head Priv.-Doz. and Deputy Director Dr. Claudia Wild Dr. Ingrid Zechmeister-Koss, MA Principal Investigators: 2 postdocs : 3 master students: 1 BA student: 1 scientific specialist: 5 administrative staff: 3 assistants: 2 other contractors: 10 Federal Ministry of Health (AT) Main Austrian Social Insurance Association (AT) nine Sickness funds of the federal states (Burgenland, Carinthia, Lower Austria, Upper Austria, Salzburg, Styria, Tyrol, Vorarlberg, Vienna) (AT) COMMITTEE Scientific Advisory Committee University. - Professor Mark Petticrew University of London School of Hygiene and Tropical Medicine (UK) - Professor. Dr. Gert van der Wilt Ramboud University Medical Center Nijmegen (Netherlands). Medical PhD. Angela Brand MPH University. PD, PhD, Institute of Genomics for Public Health Maastricht (Netherlands, Germany). Dr. Stefan Sauerland, MD MPH Institute for Quality and Efficiency in Healthcare (Germany). en Marianne Klemp Norwegian Knowledge Center for Health Services (NO) See Institute Video 34 Ludwig Boltzmann Institute LBI Health Technology Assessment 35

19Ludwig Boltzmann Institute Clinical-Forensic Imaging 5 years LBI CFI: New business and expansion of scientific activities Launching activities in Austria Clinical-Forensic Network Styria CSI? Round table with (from left to right) Minister of Justice Thomas Mühlbacher, City Council member Daisy Kopera, Vice-Chancellor Martin Polaschek, Director of the LBI CFI Institute Eva Scheurer, Member of the State Council Eduard Hamedl, Director Hannes Hofmann reviewed a very successful The conference celebrated its 5th anniversary in 2013 in terms of events. Structure The establishment of the new association has lasting strategic significance for the Institute: The Federal Ministry of the Interior, represented by Major General Gerhard Lang, decided to support the research objectives of the LBI CFI. The cooperation mainly takes place within the scope of digital communications protected by the Data Protection Act for the transmission of forensically sensitive data. Science During the 6th Call for Proposals for the Styrian Future Fund Exciting Science, LBI CFI received a grant from the Styrian Clinical-Forensic Network project (Project Manager: Dr. Reingard Riener-Hofer). The goal of the research project is to create an interdisciplinary network of regional investigative centers where victims of violence can be forensically quickly examined and their injuries documented. In addition, data and facts must be collected and evaluated scientifically during the project. Within the framework of the 2013 funding program HTI:Tech_for_Med, the Standard_MRT project is carried out in cooperation with the Technical University of Graz (Project Management: Personal Professor of Dr. Eva Scheurer). The proposed project aims to develop new strategies to segment and visualize MR data. In the long run, this should enable computer-aided evaluation of MR data for certain clinical questions. Together with the Graz University of Technology, the LBI CFI has received another grant as part of the Marie Curie program for the project Automatic age assessment from hand-held MR images. Dr. Darko Stern from Marburg started the research work in May 2013. Priv.-Doz. Dr. Eva Scheurer completed her forensic qualification training at the Medical University of Graz in March 2013 and was elected as a board member of the European Society for Magnetic Resonance Imaging in Medicine and Biology (ESMRMB) in summer 2013. Assumed this position in October 2013. Successful completion of the qualification as Director of the Eva Scheurer Institute of Forensic Medicine Photo: Rector Josef Smolle, Eva Scheurer Events In 2013, the LBI once again invited CFIs to participate in several conferences, seminars, training sessions and expert discussions. As part of the Interdisciplinary World Lecture Series on Imaging Law, experts from forensic science, imaging and medical law gave lectures on topics related to the Institute's main research areas. A half-day seminar at the Lawyers' Academy of Clinical Forensic Medicine aimed at training lawyers and legal trainees in clinical forensic medicine (Lecturer: Personal lecturer of Dr. Eva Scheurer). In March 2013, the FIRM-Aktuell event on Clinical Forensic Science and Medical Law, Present and Future took place in Graz with a good attendance and welcomed many people from experts and politicians. As part of a panel discussion on the future vision of forensic science, representatives of the Federal Ministry of the Interior, the Federal Ministry of Labor and Social Affairs, the Federal Ministry of Health, and medical associations discussed victim protection and forensic science. To celebrate its 5th anniversary, the institute was invited to tour its premises in June. The Institute's research and service areas were showcased as part of an interactive segment, and a musically accompaniment buffet that followed provided the opportunity for interesting discussions and enjoyable meetings. In order to optimize cooperation and coordination of acts of violence against the population in the Graz and Styria regions, regular working groups consisting of representatives of criminal law, criminal police, clinical medicine and forensic science meet every two months. 1 Malli N, Ehammer T, Yen K, Scheurer E. Detection and Characterization of Traumatic Scalp Injury Using Computed Tomography for Forensic Evaluation. Int J Legal Med, 127(1): (2013). 2. Scheurer E, Schoelzke S. Consent for Forensic Radiology Examination of Living Crime Victims. International Journal of Medical Law, 45(4) (2013). 3. Riener-Hofer R. Imaging and Forensic Science: Forensic Science. In: Criminology Independent Journal of Criminal Science and Practice; Verlagsgruppe HJR GmbH Kriminalistik Verlag (ed.), 11/2013: (2013). 4. Kainz S, Scheurer E, Schick P, Riener-Hofer R. Determination of the status of Austrian forensic science. Evaluation of a scientific study. In: Austrian Judges Bulletin; (ed.), 10/13: (2013). 5. Yen K, Hassler E, Scheurer E. Clinical Forensic Imaging. In: Clinical Forensic Medicine: A Multidisciplinary Practice Guide for Physicians, Nurses, Lawyers, and Relatives of Violence Victims; Grassberger M, Türk E, and Yen K (eds.), Springer Wien, New York: (2013). Ludwig Boltzmann Institute for Clinical Forensic Imaging Universitätsplatz 4/2, 8010 Graz Head Priv.-Doz. en dr en Eva Scheurer Associate Director Dr. en Reingard Riener-Hofer Principal investigators: 5 Ph.D. Students: 5 Diploma students: 1 Academic staff: 5 Scientific staff: 6 Administrative staff: 4 Medical University of Graz (AT) Graz Higher Regional Court (AT) Karl-Franzens-University of Graz Department of Graz Criminal Law , Criminal Procedure Law and Criminology (AT) Heidelberg University Hospital Department of Forensic and Traffic Medicine (DE) Siemens AG Austria (AT) Federal Ministry of the Interior (AT) COMMITTEE Scientific Advisory Board Prof. Gustav Strijkers Institute for Biomedical Engineering Eindhoven , Professor at the University of Technology (Netherlands). MD Karl-Olof Lövblad HCUG, Neuroradiology Consortium, Geneva (CH) Prof. Dr. Zurich University (CH) Walter Baer Institute for Legal Medicine. PhD teaches at Dorothee Auer University of Nottingham Queen's Medical Center Campus (UK). Ph.D. Hansjürgen Bratzke Center for Forensic Science, University of Frankfurt (Germany) Watch a video about the Institute 36 Ludwig Boltzmann Institute LBI Clinical Forensic Imaging 37

20Sustainable integration of the research competence of the Ludwig Boltzmann Institute's cancer research LBI CR in the Austrian research field Bernd Pulverer (left) presented the first poster prize to Jan Pencik (right) for the title "Loss of IL -6 or Stat3 cancer drives advanced prostate” presentation by promoting p53 inactivation at the I LBG Health Sciences Conference. The Ludwig Boltzmann Institute for Cancer Research (LBI CR) can look back on a successful 2013, achieving important organizational goals without losing sight of excellent scientific results. Published 26 papers, with a cumulative impact factor of 161, high-level scientific output. The organization's goal LBI CR 2013 enables the ambitious long-term goal of strengthening expertise and anchoring it in the field of Austrian research. One of the specifications of the scientific committee is to maintain the critical mass of the Institute. With the hiring of Dr. Florian Grebien therefore hired a new senior manager as junior team leader who would otherwise have gone abroad. This is also through the LBG's financial commitment to performance-oriented third-party fundraising for junior groups, and through ongoing adjustments to the LBI CR for the three endowment chairs, effective February 2014. Currently, the research group is led by Ph.D. Grebien was established to study the development of myeloid leukemia using the most modern methods. Also, facilitate third-party fundraising for this group, with the support of professional grants management. With the establishment of three cancer research chairs funded by the LBG, the Medical University of Vienna and the University of Veterinary Medicine, the leader in laboratory animal pathology, has kept in mind the goal of sustainable integration of successful structures in Austrian research. Experimental Animal Medicine, Translational Methods in Cancer Research, and Transgenic Models in Cancer Research, according to published international standards. Following a hearing, three LBI CR team leaders (Richard Moriggl, Lukas Kenner and Emilio Casanova) were appointed. Through their work at LBI CR, all three scholars have been able to significantly develop their expertise as points of contact for endowed professorships. In this way, scientific expertise is integrated into the university structure, even after the funding period has ended. LBI CR acts as a bridge between various partners. Its well-trained scientists can continue Austrian research at the university. Scientific Aims The LBI CR aims to conduct research of international renown in a highly competitive branch of science. LBI CR not only conducts basic research focused on the production and use of transgenic mouse cancer models, but also conducts in-depth research into direct comparisons to human disease and the use of these model systems for targeted therapy. This aims to investigate new interactions between genes or their influence on key pathways in cancer development and progression. In 2013, two research papers stood out and were about to be published, but have been successfully published in international conferences. Both projects involve our own newly developed tumor models that have been molecularly characterized in detail during long-term research work. In collaboration with his partner CCRI, Richard Moriggl successfully developed the world's first Ewing sarcoma model. LBI CR looks forward to making significant advances in the study of the pathophysiology of this rare pediatric oncological disease while establishing new therapeutic approaches. Using a new prostate cancer model, Lukas Kenner identified a hitherto unknown interaction between loss of the transcription factor IL-6/Stat3 and the tumor suppressor p53 that dramatically accelerates prostate cancer metastasis. The world's first mouse model of Ewing's sarcoma, like human tumors, is characterized by a strong invasion of bone. 1. Kantner, H.-P., Warsch, W., Delogu, A., Bauer, E., Esterbauer, H., Casanova, E., Sexl, V., and Stoiber, D. (2013). ETV6/RUNX1 induces reactive oxygen species and leads to DNA damage accumulation in B cells Neoplasia 15, [Impact Factor: 5.9] 2. Kollmann K, Heller G, Schnleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M , Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M and Sexl V (2013) . A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis. Cancer Cells 24, [Impact Factor: 24.8] 3. Kunert, R. & Casanova, E. (2013). Recent advances in recombinant protein production. Bioengineering 4, [Impact Factor: None] 4. Rao S, Tortola S, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G , Fellner N, Glove S, Glösmann M, Pasierbek P, Schlederer M, Resch GP, Ma Y, Yang H, Popper H, Kenner L, Kroemer G, and Penninger JM. Dual roles of autophagy in a mouse model of lung cancer. national society in the press 2013 [Impact Factor:] 5. Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, and Look AT (2013). Dependence on the TYK2 STAT1 BCL2 pathway in T-cell acute lymphoblastic leukemia cancer discovery 3, [Impact Factor:] Dr. Ludwig Boltzmann Cancer Institute Währingerstraße 13a, 1090 Wien Head Univ.-Prof. Richard Moriggl Associate Director Univ.-Prof. Dr. Lukas Kenner Principal investigators: 2 PhD students: 15 Diploma students: 4 Scientific staff: 6 Administrative staff: 2 Assistants: 1 Institute of Molecular Pathology (AT) Medical University of Vienna (AT) St. Anna Childhood Cancer Research (AT) TissueGnostics (AT) Veterinary University of Vienna (AT) Committee Scientific Advisory Board Prof. Nancy Heins Friedrich Michel Institute (CH ) professor. Gustavo Leone Comprehensive Cancer Center Professor Thomas Look Ohio State University (USA) Professor Radko Skoda University Hospital Basel (Switzerland) Harvard Medical School (USA). University of Nebraska Kay Uwe Wagner Medical Center (USA) Watch a video about the Institute 38 Ludwig Boltzmann Institute LBI Cancer Research 39

21Ludwig Boltzmann Institute's Pulmonary Vascular Research new perspective on the process of pulmonary vascular remodeling SrcTK TASK-1 BRAIDED Image shows the localization of TASK-1 potassium channel (red) and Src tyrosine kinase (Src tyrosine kinase, Src ). Far right The image (combined) shows that these two structures co-exist in human lung cells. Thus, Src tyrosine kinases can significantly affect potassium channel function. When the tyrosine kinase is blocked by a drug, the potassium channel can no longer function. This condition causes significant pulmonary vasoconstriction. (Nagaraj et al. European Respiratory Journal 2013, 41:85-95) Until a few years ago, lung transplantation was the only hope for patients with pulmonary vascular disease. But now there are drugs to treat it. However, these do not prevent the development of the disease. Therefore, there is an urgent need to study signaling pathways to develop new therapeutic approaches. Grazyna Kwapiszewska's group at the Ludwig Boltzmann Lung Vascular Institute (LBI LVR) focused on the transcription factor Fra-2 and its mediator mephrin-ß during vascular transformation. Fra-2 causes pulmonary vascular proliferation, which may lead to pulmonary hypertension and pulmonary fibrosis. Blocking this signaling pathway can have a positive effect on the conversion process in the lung. This new approach is currently being developed with our partner Bayer HealthCare. In another study, the task force is investigating the development of pulmonary hypertension as a side effect of other independent therapies. LBI LVR enables deciphering the cause of dasatinib-induced pulmonary hypertension in hematological patients. Studies have shown that the drug can block an important ion channel in lung cells, causing significant pulmonary vasoconstriction. In addition, Leigh Marsh and her team have set themselves the goal of developing a new drug delivery system that delivers the drug directly to the lungs via a nebulizer. The stated goal of the LBI LVR is to generate easy-to-use automated software for the non-invasive diagnosis of pulmonary hypertension. To this end, last year Zoltán Bálint's group developed an automatic algorithm to identify pulmonary vessels in computed tomography images. This new method may represent an opportunity to determine pulmonary hypertension non-invasively. This will make a new technique for detecting pulmonary hypertension available to the public as part of early routine screening. In the next few years, efforts will be made to develop quantitative software for clinical use. Gabor Kovacs' group sees creating a large clinical database, or cohort, of pulmonary vascular disease as one of their most important tasks in gaining new insights into the development of pulmonary arterial hypertension. In addition to extensive clinical data, blood samples are also collected and stored in the biobank of the Medical University of Graz. Over the past two years, LBI LVR has successfully established a large cohort of healthy patients and volunteers. Using these samples, several studies were conducted in 2013 to identify new biomarkers for the detection and prognosis of pulmonary arterial hypertension. Several promising candidates have been characterized. Studies involving several international centers have been initiated to test these new biomarkers. Another focus of this working group is the study of the physiological properties of the pulmonary circulation. Endothelial cells Endothelial microparticles Fibroblasts Adventitia Smooth muscle cells Myofibroblasts Circulating mediators and cells are potential biomarkers for pulmonary vascular disease. This figure shows the structure of the pulmonary vessels and the biomarkers that may be involved in vascular remodeling. ADMA = asymmetric dimethylarginine; ADR = adrenomedullin; BMPRII = bone morphogenetic protein receptor type 2; CGRP = calcitonin gene-related peptide; CM = cell marker; ET1 = endothelin 1; NO = nitric oxide; PGI2 = prostacyclin. (Foris et al., CHEST 2013, 144: ) Ongoing research continued in 2013 in the area of ​​early detection of pulmonary arterial hypertension. With the application approved by the Austrian National Bank, it was possible to start a new series of studies in 2014 involving the determination of lung blood pressure and heart function using non-invasive methods (magnetic resonance imaging and echocardiography). To inform the public about the work of the LBI LVR, a conference was organized in September 2013 together with the Medical University of Graz, which was attended by more than a hundred affected persons and their families. 1. Biasin V, Marsh LM, Egemnazarov B, Wilhelm J, Ghanim B, Klepetko W, Wygrecka M, Olschewski H, Eferl R, Olschewski A, Kwapiszewska G. Meprin beta, a new mediator of vascular remodeling in pulmonary arterial hypertension. J Pathol November 20 doi: /path [Epub ahead of print] 2. Nagaraj C, Tang B, Bálint Z, Wygrecka M, Hrzenjak A, Kwapiszewska G, Stacher E, Lindenmann J, Weir EK, Olschewski H, Olschewski A . The Src tyrosine kinase is essential for human pulmonary arterial potassium channel function. Eur Respir J Jan; 41(1): Pienn M, Kovacs G, Tscherner M, Johnson TR, Kullnig P, Stollberger R, Olschewski A, Olschewski H, Bálint Z Determination of cardiac output by dynamic contrast computed tomography. Int J Cardiovasc Imaging 29(8): Foris V, Kovacs G, Tscherner M, Olschewski A, Olschewski H. Biomarkers of pulmonary hypertension: what do we know? Chest. 2013;144(1): Kovacs G, Avian A, Olschewski A, Olschewski H. Zero reference levels for right heart catheterization. European Respiratory Journal 2013; 42(6): Ludwig Boltzmann Institute for Pulmonary Vascular Research Stiftingtalstraße 24, 8010 Graz Head Univ.-Prof. en dr en Andrea Olschewski Deputy Director Dr. en Grazyna Kwapiszewska Principal Researchers: 3 postdocs: 15 doctoral students: 4 diploma students: 2 master students: 2 scientific staff: 7 administrative staff: 5 Bayer Pharma AG (DE) NEBU-TEC (DE) Graz Medical University ( AT ) ) Committee Prof. Steve Abman, PhD, University of Colorado (USA) and Professor Sally-Ann Cryan, Royal College of Surgeons (IE). Wolfgang Kübler University of Toronto (CA) & Universitätsmedizin Berlin (DE) Prof. Jose Lopez-Barneo University of Seville (ES) Prof. University of California Dean Sheppard (USA) Watch Institute Video 40 Ludwig Boltzmann Institute LBI Pulmonary Vascular Research 41

22Ludwig Boltzmann Institute for Human Rights strengthens the structure for the protection of human rights Shows the number of project examples of the work of the Ludwig Boltzmann Institute for Human Rights (BIM) at a high level, Vienna +20: , from Left to right: Amnesty International Secretary-General Salil Shetty; UN High Commissioner for Human Rights Navi Pillay; Austrian Foreign Minister Michael Spindelegger; Jan Eliasson, UN Assistant Secretary-General; Tawakkol Karman, Yemeni Women's Rights Campaign Nobel Peace Prize winner; Russian human rights defender Ludmilla Alexeeva (Photo: Dragan Tatic, CC BY 2.0) On the human rights agenda, 2013 was also the focus of the 20th anniversary of the World Conference on Human Rights in Vienna, so BIM was involved in the design of the Vienna +20 Conference: Cooperation with the Austrian Foreign Office to promote human rights protection. BIM researchers prepared a number of background studies as well as publications for the conference, which brought together human rights experts from around the world in Vienna. Recommendations to the UN General Assembly include strengthening cooperation among national, regional and international human rights mechanisms, developing effective remedies for victims of human rights violations, and protecting human rights defenders. The direct link between BIM work and current events was evident at European and Austrian levels in 2013: BIM experts, as part of a twinning project to support Turkish police in preventing excessive use of force, supported how the police dealt with the political unrest in Turkey. The violent response to the demonstrations and the international announcements about them demonstrate how important it is for the police to act in a professional and human rights-compliant manner to protect and guarantee the fundamental rights to freedom of expression and assembly in democracies. The results of BIM's survey on the situation of imprisoned youth, completed in spring 2013, were published in time for youth in custody to experience violence in Austria as well. Recommendations made during the engagement process with young people have been fed directly into subsequent discussions on judicial reform. The two-year Access to Victim Protection Services for Women with Disabilities project, launched in 2013, also aims to improve the situation of victims of violence and examines the institutional support women with disabilities receive in Austria, Germany, the United Kingdom and Iceland. In this research project, an equally special requirement was that the research be carried out not only with the affected people, but also with them, i.e. both researchers with and without disabilities were actively involved in the project team. advisory board. BIM experts on behalf of the EU Fundamental Rights Agency have written a Handbook on European Data Protection Law, which was launched at the Data Protection Day 2014 conference in Brussels. The handbook mainly deals with the applicable law on data protection and is suitable for lawyers and data protection authorities as well as ordinary people who face legal problems in data protection. Research project "Migration due to climate change and the need for new regulatory and institutional frameworks", completed in 2013, in which, p. prepared case studies of six affected countries and will continue in 2014, focusing on Austria and the EU's responsibility for climate policy in third countries. At the end of the same year, the anti-torture project "Atlas of Torture" was completed. The team's experience in monitoring will now feed into a research project on the European National Preventive Mechanism and Strengthening of Kyrgyzstan's Structures to Combat Torture. Preventive monitoring of prisons: face-to-face training of criminal defense lawyers in Tacumbú prison, Paraguay, as part of the Atlas de la Tortura project In addition to working internationally, an important step was taken at the local level in 2013: in the international human rights arena On 10 December, the City of Vienna started the process of making human rights a priority in city policy. BIM will scientifically accompany this process in the coming years. 1. Manfred Nowak, Julia Planitzer: Trafficking in Human Beings Equivalent to Torture and Other Forms of Ill-treatment - A Legal Analysis, OSCE Interim Paper Series No. 1. 5. Hannes Tretter: A European Legal Framework to Combat Hate Speech, in Feik/Winkler (eds.), Festschrift by Walter Berka, Margit Ammer et al. al: War and torture in the asylum process. A study of psychotherapy and law. Research Series of the Ludwig Boltzmann Institute for Human Rights, Vol. Johanna Lober: Implementation of the Optional Protocol to the United Nations Convention against Torture in Europe, in Human Rights Yearbook 2012/2013. Edited by Heiner Bielefeldt et al. Barbara Linder, Karin Lukas, Astrid Steinkellner: The right to a remedy. Out-of-court complaint mechanism for addressing conflicts of interest between business actors and persons affected by their activities, 2013 Ludwig Boltzmann Institute for Human Rights Freyung 6 (Schottenhof), 1. Hof, Stiege II, 1010 Wien bim.staatsrecht@univie. holder university - prof. Manfred Novak et al. University Professor Hannes Tretter Administrative Manager Mag. Patricia Hracik Magazine. To Fiona Steinert Principal investigators: 3 Postdocs: 5 PhD students: 4 Master students: 1 Academic expert: 9 Administrative staff: 5 Other contractors: 74 Administrative staff: 5 University of Vienna, Research Platform EU Human Rights in Context (TA) European Union Fundamental Rights Agency (EU) Association of Human Rights Institutes (Global) RD Vienna Foundation. Research Development Human Rights (TA) Austrian Development Cooperation and the Federal Ministry for European and International Affairs (TA) Watch a video about the Institute 42 Ludwig Boltzmann Institute LBI Human Rights 43

23Volume cover The Neo-Latin novel as a medium for its time The Neo-Latin novel in its time, Tübingen: Narr 2013 Ludwig Boltzmann Institute for Neo-Latin Studies Novels And Illustration: Surprising Field Of Influence OF Neo-Latin Tfan Tilg and Isabella Walser were able to publish the first volume of the Ludwig Boltzmann Institute for New Latin Institute (LBI Neulatin) conference publish: The Neo-Latin novel as a medium of its time The Neo-Latin novel in its time, Tübingen : Narr It appears in the famous new Latin series, the first major release so far. Little noticed, because it is aimed at an interdisciplinary audience, the book specifically examines the modern implications of neo-Latin fiction writing. In addition, Isabella Walser was able to publish a revised edition of her diploma thesis on the Trentino illuminator Giovanni Battista Graser in the series Tirolensia Latina: In the Teresian Age of Reason Giovanni Battista Graser: De praestantia logicae, Innsbruck: Wagner's Teaching Poetry Graser, the logic of translation and commentary in this volume, is a model of the Latin Enlightenment, a progressive stream of Latin literature that has recently received increasing attention and clearly contradicts the outdated image of Neo-Latin literature as regressive. Another highlight were the four conferences organized by LBI Neulatin in 2013. In collaboration with the Pontificio Comitato di Scienze Storiche, Oren Margolis (LBI Neulatin) and Graham Barrett (St John's College, Oxford) at the Vatican on "Latinness in the Post-Classical World" (April). Here, researchers from various disciplines highlight the history of Late Old Latin. The Lower Franconia Humanitarian Symposium (Thomas Baier, University of Würzburg; Stefan Tilg, LBI; Würzburg, July) attempted to assess humanitarianism in Würzburg and integrate it into a wider context. Participants of the conference "Latins in the post-classical world" in front of Fontana Paola in Rome "Feats of crossing mountains and climbing peaks" conference (Martin Korenjak, LBI; Robert Rollinger, University of Innsbruck) also present with BM's daughter and authors R. Schrott; Michael Kasper, Montaverna Museum; Andreas Rudigier, Vorarlberg State Museum; Schruns, October) tracked changes in perception of mountains over time, and LBI Neulatin.Br also studied A series of monographs and related editions (probably first published in 2015). Additionally, Latin at the Crossroads of Identity: The Evolution of Linguistic Nationalism in Hungarian Enlightenment, edited by Gábor Almási and Lav Šubarić, aims to shed new light on the ethnic conflicts of the Eastern Habsburgs. LBI has access to third-party funding for Neulatin through a cross-border grant from the Republic of Croatia and a grant from the Tyrolean Science Foundation. In 2014, these will lead to the Tyrolean and Croatian Latin Text Digital Recording Project, where LBI New Latin led by Lav Šubarić will collaborate with a Croatian working group led by N. Jovanović. Finally, a number of conferences are planned for 2014. LBI Neulatin, inter alia, presented at the "Changing Hearts: Manifesting Jesuit Emotions Between Conferences in Europe, Asia and the Americas" conference (Cambridge, Trinity College, March) and presented his contributions to Jesuit drama, poetry and narrative prose Research. 1. S. Tilg / I. Walser (ed.), The Neo-Latin Novel as Media for its Time The Neo-Latin Novel in its Time, Tübingen: Narr I. Walser, In the Teresian Age of Reason Giovanni Battista Graser : De praestantia logicae , Innsbruck: Wagner M. Korenjak, Pulcherrimus foecundissimusque Naturae hortus: Reports on Botanical Mountaineering in the 16th Century, Neulatines Jahrbuch 15 (2013), O. Margolis, Cyprian de Maris St - Lucianic Speech for Anjou Dié, MS 37): Humanism and diplomacy in the future, Renaissance Research 27 (2013), M. Korenjak, Thomas Schoepf's Inclitae Bernatum Urbis Delineatio Chorographica, Cartographica Helvetica 47 (2013), L. Udwig Boltzmannstitutnür Neulatine Studien Weg 11, 6020 Innsbruck Office .that Director Dr. Stefan Tilg Associate Director Dr. Lav Šubarić Principal Investigators: 1 Postdocs: 9 Doctoral Students: 9 Graduate Students: 1 Administrative Staff: 1 University of Innsbruck (AT) University of Freiburg i. Br. (DE) Austrian National Library ( AT) Pontificio Comitato di Scienze Storiche (VA) COMMITTEE Scientific Advisory Committee Prof. Dr. Henk Nellen Huygens Institute, History of Science, The Hague (NL). Dr. Peter W. Marx Department of Theater and Media Culture (DE) University of Cologne Prof. Dr. Dirk Sacré Katholieke Universiteit Leuven, Seminarium Philologiae Humanisticae (BE) Prof. Dr. Frankfurt (DE) Prof. Robert Seidel Goethe University Dr. Hermann Wiegand Ruprecht-Karls - Heidelberg University (Germany) Watch a film about the Institute 44 Ludwig Boltzmann Institute LBI Neolatin Studies 45

24Scientific Reports from Ludwig Boltzmann Institute Operative Laparoscopy LUDWIG BOLTZMANN Institute for Laparoscopic Surgery (LBI OPLAP): Surgical Research, Conferences and Courses Participants practiced exercise models as part of a co2 basic gas study with randomized use of laparoscopy and humidified exercise. Laparoscopic gallbladder surgery versus standard carbon dioxide gas: the study has been concluded and submitted for publication in the journal Surgical Endoscopy. It was presented at the Austrian Congress of Surgeons. 1470 nm Laser Endoluminal Occlusion of the Saphenous Vein and VNUS Rapid Closure: The study is in its final stages and patients are still being recruited A new multicenter prospective randomized study production: continuous loop suture technique for abdominal wall closure technique between short and long needles. A total of three clinics from Austria participated in the study (Wilhelminenspital, Universitetsklinik Salzburg, AKh Linz). The protocol has been drafted and has been approved by the ethics committee. Start: March One of the focuses of the University of Linz will be geriatric medicine. LBI OpLap has initiated a prospective analysis of oncology/colorectal surgery outcomes in patients over 80 years of age. The first results have already been presented in St. Louis. Proceedings of the International Colorectal Cancer Congress. International Surgical Innovation Congress: This event is held in Linz and Salzburg in cooperation with the Salzburg Hospital der Barmherzige Brüder. (150 participants from all over the world). Four international surgeons and Doz performed five operations at the Linz General Hospital. Shamiyeh, Linz General Hospital. These operations are transferred on the one hand to the AKh conference room and on the other hand to the Salzburg Congress Center. The symposium, held for the third time, is currently considered the latest event in Europe dealing with the development of the latest surgical techniques, minimization of access trauma and pain relief. Under the leadership of Rene Fortelny, the LBI OpLap, together with trade unions and the University Hospital of Salzburg, organizes the Salzburg Brothers Day as a partner. An activity focused on the rehabilitation of groin, abdominal wall and diaphragmatic hernias. In addition to hosting and teaching in Salzburg, international visiting surgeons perform operations at the Linz General Hospital. The action was broadcast in the AKh conference room and the Salzburg Congress Centre. Other activities: Laparoscopy Colon Surgery Five Surgery Courses Linz Laparoscopy Days Phlebology Basic course Patient blood treatment Mammaforum Linz Senology Symposium etc. LBI OpLap is participating in a multicenter study of abdominal wall closure. A study with two centers is also planned from March: comparing single-incision surgery with standard 4-port laparoscopic surgery for colorectal surgery, with the main issues being pain and incisional hernia and complications. The protocol was written and the project was submitted to the ethics committee. The partner is Klinikken St. Gallon of Switzerland. It is also planned to participate in a multicenter study at the Memmingen Clinic in Germany comparing early elective laparoscopic versus elective laparoscopic resection of diverticulitis (after 6 weeks). Here they discuss and prepare with Prof. Guth at the Memmingen Clinic. Also planned: comparison of therapeutic split ERCP for bile duct stones in a two-stage procedure (i.e. bile duct repair). ERCP is performed first, followed by laparoscopic cholecystectomy with bench-top ERCP 2-3 days later, a one-step simultaneous procedure. Inception: Herbst Haas D, Oppelt P, Shebl O, Chvatal R, Shamiyeh A, Mayer R, Binder H. (2013) Allen-Master syndrome: Do classical risk factors also apply in patients with endometriosis? J Obstet Gynecol Res. doi:/jog [Epub ahead of print] 2. Prast J, Oppelt P, Shamiyeh A, Shebl O, Brandes I, Haas D. Costs of endometriosis in Austria: a survey of direct and indirect costs. Arch Gynecol Obstet. 288(3): Haas D, Oppelt P, Shebl O, Shamiyeh A, Schimetta W, Mayer R (2013) Gentian classification: does it correlate with clinical symptoms and rasrm score? Acta Obstet Gynecol Scand. 92(5): Haas D, Wurm P, Shamiyeh A, Shebl O, Chvatal R, Oppelt P (2013) Validity of the revised classification of gentians: a retrospective analysis. Does the modified gentian classification solve the dual classification problem of rasrm and gentian? Arch Gynecol Obstet. 287(5): Ludwig Boltzmann Institute of Surgical Laparoscopy AKh Linz City General Hospital GmbH Hospital Street 9, 4020 Linz Head Univ.-Prof. Dr. Wolfgang Way and Deputy Director Prim. University - Doz. Dr. Andreas Shamiyeh Administration: 2 The LBI surgical laparoscopy team is complemented by scientists and physicians who carry out research activities at LBI as part of their hospital work, but who are not LBG employees. Linz City General Hospital (AT) Watch Institute Video 46 Ludwig Boltzmann Institute LBI Surgical Laparoscopy 47

25Ludwig Boltzmann Institute of Osteology Institute Bone Clinical Research Topic Mineralization disorders due to renal disease in children and skeletal changes caused by immobilization in comatose patients An international research award was awarded to the Department of Orthopedics of the Prof. Ludwig Boltzmann Institute (LBI), which last year could investigate a special case of bone disease. On the one hand, studying a unique set of hip flexion deformities in children with renal disease, on the other hand, LBI is dedicated to studying the topic of inactive osteoporosis in comatose patients, which until now has been largely ignored clinically. Neglected. Chronic kidney disease (CKD) causes disturbances in mineral metabolism, bone remodeling, bone mineralization, and changes in existing bone mass. Growth disturbances are especially common in children with CKD. In the LBI Osteologie Study, paired hip biopsies from children on dialysis before and after growth hormone therapy could be examined (courtesy of collaborators at LBI Osteologie, Warsaw Medical University). Before treatment, the bone turnover rate was abnormally low, and the calcium concentration in the bone matrix was significantly higher than normal. After one year of growth hormone therapy, the younger patients experienced increased height and increased bone turnover to normal values ​​or more, which could be measured in biopsies. In addition, the treatment reduced the average calcium concentration in trabecular and cortical bone to normal levels. These results suggest that growth hormone therapy has a beneficial effect on bone turnover and mineralization in children with CKD. This work was published in Am J Kidney Dis in 2013. 61(5): Published and awarded Dr. Herbert Czitober with the Best Article Award for Clinical Skeletal Research Austria. a Kamilla Nawrot-Wawrzyniak (LBI Osteology). Other work deals with the skeletal effects of immobilization on comatose patients. Lack of exercise and stress can lead to a dramatic, rapidly progressive, and marked loss of bone mass in weight-bearing areas of the skeleton. In this context, a five-year study of bone mineral density and serum bone turnover markers in Appalachian vegetative patients at the Wienerwald Center for Geriatrics in Vienna was compared with data from healthy individuals of the same age. .Vitamin D deficiency in comatose patients has relatively low serum calcium levels and markedly elevated bone turnover markers. Bone density in the hips and spine decreased significantly. During the observation period, non-traumatic fractures occurred in 20% of patients. These data suggest that immobilization of comatose patients results in increased bone resorption and decreased bone mass, and that the occurrence of nontraumatic fractures is a clinically relevant problem in these patients. This work was published in J Bone Miner Res on October 28. Doi:. It should also be mentioned that LBI Osteology has successfully continued to focus on the study of the effects of bisphosphonates on bone material as well as bone and tumor cells. Dr. Roman Thaler (LBI Osteology) 2013 oegkm Jakob Erdheim Award for Best Basic Research Paper for the study of the epigenetic mechanism of action of ibandronate in tumor cells. Further research into the effect of osteoporosis treatment on bone material is planned this year, with a focus on anabolic parathyroid hormone treatment. In addition to these clinical focuses, many basic research topics continue, eg. For example, the precise processes involved in bone matrix mineralization in healthy individuals need further study. 1. Misof BM, Roschger P, Gabriel D, Paschalis EP, Eriksen EF, Recker RR, Gasser JA, Klaushofer K 2013 Three years of annual intravenous zoledronic acid increases cancellous bone above normal in the HORIZON biopsy cohort Matrix mineralization. J Bone Miner Res 28: Gamsjaeger S, Hofstetter B, Zwettler E, Recker RR, Gasser JA, Eriksen EF, Klaushofer K, Paschalis EP 2013 Effect of three years of once-yearly zoledronic acid treatment on bone matrix maturation kinetics in bone mass Osteoporosis Int 24 in Osteoporotic Patients: Thaler R, Zwerina J, Rumpler M, Spitzer S, Gamsjaeger S, Paschalis EP, Klaushofer K, Varga F 2013 Homocysteine ​​Induces Osteoblasts in Osteoblasts by Unlocking the RGD Motif Serum A3 amyloid. FASEB J 27: Nell-Duxneuner V, Axmann R, Husar-Memmer E, Dallos T, Datz C, Stadlmayr A, Aigner E, Englbrecht M, Schett G, Zwerina J 2013 Serum VCAM-1 levels and hereditary hemochromatosis Arthropathy related. Ann Rheum Dis 72: Nawrot-Wawrzyniak K, Misof BM, Roschger P, Panczyk-Tomaszewska M, Ziółkowska H, ​​Klaushofer K, Fratzl-Zelman N 2013 Changes in bone matrix mineralization after hormone therapy in children and adolescents treated with dialysis Chronic renal failure: a paired biopsy study. Am J Nephrology. 61: Moffatt P, Ben Amor M, Glorieux FH, Roschger P, Klaushofer K, Schwartz S, Schwartzentruber JA, Paterson A, Hu P, FORGE Canada Consortium, Majewski J, Beaulieu C, Boykot KM, Rauch F 2013 Maxillary metaphysis Dysplasia and brachydactyly are caused by duplications of RUNX2. Am J Hum Genet 92:252-8 Ludwig Boltzmann Institute of Osteology Heinrich-Collin-Strasse 30 (Hanusch-KH), 1140 Vienna Kundratstrasse 37 (UKH Meidling), 1120 Vienna Prim. Director University Professor. Dr. Klaus Klaushofer Principal Investigator: 5 Postdocs: 11 Doctoral Students: 2 Scientific Specialists: 7 Administrative Staff: 1 Assistant: 4 Other Contractors: 3 Medellín Accident Hospital General Accident Insurance Agency (AT) ha Nusch Fund Hospital Vienna Regional Health Insurance (AT) Board DG DI Peter Vavken AUVA (AT) DG Mag. Erich Sulzbacher WGKK (AT) Deputy Chairman Manfred Anderle WGKK (AT) ÄD Dr. Andreas Greslehner AUVA (AT) Dr. Johannes Pflug Vienna Chamber of Commerce (AT) ) President Mag. To Prof. Senator Ingrid Reischl WGKK (AT). mag. Dr. Günther Schön Prim. For Dr. Elisabeth Zwettler Hanusch-KH from WGKK (Austria) Watch a film about the Institute 48 Ludwig Boltzmann Institute LBI Osteology 49

26Three Ludwig Boltzmann Retinology and Biomicroscopy Laser Surgery Institutes (LBI RETINA) with major advances in different areas of research In 2013, the complete international study was published in International Research 2013. The ROVO study investigated the effectiveness of radial optic neurotomy in central vein occlusion. The MANTA trial compared the intravitreal agents ranibizumab and bevacizumab in AMD, and the CABERNET trial evaluated transscleral macular brachytherapy in AMD. In addition, the TargetAMD study continues in Europe, where the Ophthalmology Department of the Rudolfstiftung Hospital, where LBI Retina is located, is one of two clinical centers (other center: Geneva). All other European centers handle cell transfection in the experimental area. The four-year project involved the transplantation of non-viral autologous retinal cells (iris and retina) genetically modified to express retinal growth factor (PEDF), which were then administered to subretinal transplants in patients with exudative AMD. The clinical applicability of the newly developed OCT technique based on the 1060 nm wavelength has been investigated in several working groups and studies. There is a close cooperation with the Department of Medical Physics and the Center for Biomedical Physics and Technology of the Medical University of Vienna. The advantage of this OCT technique is that the shorter wavelength allows a greater penetration depth and thus the entire thickness of the choroid can be assessed. In addition, 3D representation, segmentation and signal processing can be improved. In intraoperative OCT, work has been undertaken to improve the clinical applicability and informative value of this world-unique prototype. The results have also been published. A second production-ready version of this prototype is now available for LBI Retina. An international conference on this topic will be held on February 22, 2014 at the Rudolfstiftung Hospital. Results of the use of moderate-energy-density photodynamic therapy for central serous chorioretinopathy have been published. The reduced dose prevents collateral damage to the retina. In retinal surgery, the toxicity of surgical dyes has been reported, as well as the effectiveness of various surgical procedures in retinal detachment. In addition, LBI Retina was actively involved in an Austria-wide quality assurance study on vitreous and epiretinal membrane disruption with media detachment and investigated clinical outcomes in patients with macular holes. LBI Retina conducted two studies in collaboration with Weill Cornell/New York Eye Clinic. One topic is modern retinal surgery and the other topic is the behavior of the vitreous in patients with marked vitreous opacities (= floaters). In 2014, the now commercially available intraoperative OCT developed by LBI Retina will be rolled out globally. Three studies were designed on this topic. The study of choroidal changes associated with various eye diseases with 1060 depth OCT also extends to the field of preoperative and postoperative behavior of retinal and choroidal structures. EU TargetAMD project, submitted to the Ethics Committee and Bioethics Committee for clinical implementation. Vitreous surgery studies will address the use of silicone oil tamponade and the behavior of central retinal thickness (as examined by OCT). 1. Duker JS, Kaiser PK, Binder S, de Smet MD, Gaudric A, Reichel E, Sadda SR, Sebag J, Spaide RF, Stalmans P: Classification of vitreomacular adhesions, traction, and macular holes by the International Vitreomacular Traction Study Group . Ophthalmology Dec;120(12):doi:/j.ophtha Epub 2013 Sep Krebs I, Glittenberg C, Ansari-Shahrezaei S, Hagen S, Steiner I, Binder S: Macular Vascular Endothelial Growth Factor Antagonist Nonresponders Age-related degeneration. Br J Ophthalmol Nov;97(11): doi:/bjophthalmol Epub 2013 Aug Krebs I, Schmetterer L, Boltz A, Told R, Vécsei-Marlovits V, Egger S, Schönherr U, Haas A, Ansari-Shahrezaei S, Binder S ; MANTA study group: a randomized, double-blind trial comparing visual outcomes in patients with neovascular age-related macular degeneration treated with ranibizumab or bevacizumab. Br J Ophthalmol Mar;97(3): doi: /bjophthalmol Ludwig Boltzmann Institute of Retinology and Biolaser Microsurgery Juchgasse 25, 1030 Wien Head Univ.-Prof. a dr a Susanne Binder Lecturer OA a Dr. en Ilse Krebs Postdoc: 1 Research Staff: 4 Wiener Krankenanstaltenverbund (AT) Watch a film about the Institute 4. Brunner S, Mora A, Fonseca J, Weber T, Falkner-Radler CI, Oeser R, Binder S: Monitoring drusen and area size of geographic atrophy after cataract surgery using the MD3RI computer-aided contour tool. Ophthalmic. 2013;229(2): doi:/ Smretschnig E, Ansari-Shahrezaei S, Hagen S, Glittenberg C, Krebs I, Binder S: Moderate energy density photodynamic therapy for chronic central serous chorioretinopathy. Retina feb;33(2): doi: /IAE.0b013e c. PubMed PMID: Ludwig Boltzmann Institute LBI Retinology and Biolaser Microsurgery 51

27Population pays contributions to third parties, e.g. taxes, insurance Population/patient Citizens, residents, families/consumers Ludwig Boltzmann Institute of Social Psychiatry Patient 3 Patient contributes to provider payments, e.g. co-payment, co-payment diagram. 1: According to the principal-agent model (adapted from Reinhardt, 1990), the flow of funds between the three main players in the healthcare system B Third-party procurement/payment/commission/contract services. By provider, e.g. fee-for-service, capitation provider Inpatient/Day/Outpatient/Mobile Care In addition to posting completed projects, the Ludwig Boltzmann Institute for Social Psychiatry (LBI) also focuses on at the health system level around financing models and the patient journey, leading to compliance with The requirements aimed at improving the quality, distributive justice, efficiency and improvement of care for people with mental disorders. These issues were addressed as part of two third-party funded projects: As part of the EU project REFINEMENT The impact of the financing system on the quality of mental health care in Europe (DG Research, 7th RP,; LBI Social Psychiatry led the work package Description and Interpretation Functional and Dysfunctional Care Pathways and Financial Incentives in Mental Health Care) and Use of Health Services after Prescribing Antidepressants, commissioned by the Association of Large Safety Institutions, Austrian Social Organizations. In the REFINEMENT project, a survey tool was developed in collaboration with the London School of Economics to document funding systems and financial incentives for providing care for people with mental health problems (FINCENTO). To construct the survey instrument, the so-called principal-agent model in health economics was adopted and used as a guide for documenting financing mechanisms (see Figure 1). In addition to sections on policy, fundraising, and pooling, FINCENTO contains six chapters on payment mechanisms in different provider areas (primary care; outpatient mental health specialty care; inpatient mental health care; housing, employment, and vocational rehabilitation; prescription drugs; nursing Coordination). In FINCENTO, special attention is paid to the relationship between different structural conditions and economic incentives in different countries. In the REFINEMENT project, the REPATO survey tool was also developed to document patient progression (e.g. from GP to psychiatric care). At REPATO, particular emphasis is placed on continuity of care and potential influencing factors (e.g. travel time to facility, patient contribution). REPATO and FINCENTO are part of a comprehensive decision support tool designed to help political and administrative decision makers optimize mental health care. In the antidepressant project, using the so-called GAP-DRG 2006/2007 database of the main association of Austrian social insurance institutions, social insurance for a quarter (Q4 2006) with at least one prescription for antidepressants was established by the record linking method exchanged at the pharmacy, ie one in every 20 Austrians. In 2006, four out of five patients also had at least one prescription for a medical condition. Only about 3% of these patients were admitted to psychiatric units in 2007, but ten times as many (30.5%) were admitted to psychiatric units. Floors of non-psychiatric hospitals (see Figure 2). Only about one in five patients consulted a psychiatrist, while GPs and non-psychiatrists consulted much more frequently. These results, together with the finding that a striking proportion of the original population (subjects = 4.6%) died within one year, suggest a high level of comorbidity in physical disease. 0 ADPR-4/2006: All IAG-2007 reference population: Admission to non-psychiatric beds n = weeks 2007 2: People prescribed antidepressants in Austria, Q4 2006 (ADPR-4/2006): Health services in 2007 Cumulative usage LBI Social Psychiatry ended its activities at the end of June 2014 after 35 years of existence. The remainder of the time is devoted to report generation and preparation for publication. 1. Straßmayr C, Katschnig H, Amaddeo F, Brunn M, Cetrano G, Chevreul K, Cid J, McDaid D, Järvelin J, Kalseth B, Kalseth J, Malin M, Matosevic T, Pauna C, Salvador-Carulla L, Sfetcu R and REFINEMENT Group: Economic Incentives/Disincentives in Provider Payment Mechanisms and User Payments for Mental Health Care. research work. Wien Weibold B, Katschnig H, Cetrano G, Chevreul K, Cid J, Ghenea D, Kalseth B, Kalseth J, Kontio R, Malin M, Matosevic T, McDaid D, Motrico E., Prigent A., Salazzari D., Sfetcu R and the REFINEMENT group: A comparative report on differences in trajectories among REFINEMENT partner countries. Data collected through REPATO (Refined Pathways Toolkit) on typical and most common pathways for people with mental disorders. research work. Vienna % Ludwig Boltzmann Institute of Social Psychiatry Lazarettgasse 14A-912, 1090 Vienna Head Univ.-Prof. Dr. Heinz Katschnig Principal Investigator: 6 Administrative staff: 1 Austrian Social Security Institution (AT), Ioannidis E., Kluge U, Jensen NK, Lamkaddem M, Puigpinós i Riera R, Kósa Z, Wihlman U, Stankunas M, Straßmayr C, Wahlbeck K, Welbel M, and Priebe S.: Immigrant Treatment Experience: A qualitative study of mental health services in 16 European countries. Social Psychiatry & Psychiatric Epidemiology. 2013, 48: doi: /s Welbel M, Matanov A, Moskalewicz J, Barros H, Canavan R, Gabor E, Gaddini A, Greacen T, Kluge U, Lorant V., Esteban Peña M., Schene AH, Soares JJF, Straßmayr C., Vondráčková P., and Priebe S.: Addiction treatment in disadvantaged urban areas of EU countries: Access to care for socially marginalized groups. Medicines: Education, Prevention and Policy, 2013, 20: doi: / Ludwig Boltzmann Institute LBI Social Psychiatry 53

28The Ludwig Boltzmann Translational Institute for Heart Failure LBI HF carried out the largest survey of telemedicine data for heart failure in Austria and investigated new treatment options for diastolic heart failure with new drugs. In another disease model, LBI HF also demonstrated in a high-profile publication in 2013 that a new drug-based procedure that treats intracellular calcium leaks can prevent systolic heart failure in some patients Failure and malignant arrhythmias. (2). Two new researchers with excellent international experience and two new doctoral students have been added to the team to assist clinicians in developing innovative software algorithms for treatment planning. LBI HF researchers received a three-year grant from the FWF. In 2013, the LBI HF held two translational workshops at the annual meeting of cardiologists in Austria, the International Mini-Symposium on Mitochondria, Calcium and the Heart in Graz and launched an app for FFG regional talents. A project to identify heart disease through biomarker learning (funded as part of Regional Talent) links LBI HF with five participating schools (two integrators) and four scientific and business project partners. Through access and materials, students Interest in health and wellness research in the field of natural sciences as well as job descriptions and career models was awakened The LBI HF team is delighted with the extremely positive response to this collaboration Ludwig Boltzmann Institute for Research Translational Heart Failure Stiftingtalstraße 24, 8010 Graz University Director - Prof Dr. Dr. Burkert Pieske Associate Director Prof. Dr. Frank Heinzel Principal Investigators: 2 Postdocs: 11 Doctoral Students: 9 Scientific Experts: 7 Administrative Staff: 3 Assistants: 5 Ludwig Boltzmann Institute for Translational Studies Heart Failure Research (LBI HF) is the focal point for the pathophysiology of heart failure, early detection and risk stratification, and the development of new treatments. The 2013 results reflect LBI HF's active network for academic, experimental and clinical health research as well as industrial development. Novel mechanism of diastolic dysfunction demonstrated for the first time in an animal model and validated in human myocardium. The discovery of desynchronized intracellular calcium elimination opens a new field of study of diastolic cell function and has been published in the foremost international cardiovascular basic research journal (1). LBI HF has also developed a small animal model which, for the first time, displays all essential features of the clinical presentation of diastolic heart failure, allowing evaluation of new therapies with relevant endpoints. Together with partner Bayer HealthCare, a long-term treatment study was initiated in LBI HF. These studies will provide the first insight into differential gene regulation in patients with diastolic and systolic dysfunction, as a starting point for new possible therapeutic targets. Since 2013, the LBI HF Echocardiography Core Laboratory has all the necessary resources to characterize cardiac function using state-of-the-art experimental methods as an interface between basic research and clinical practice. It was also listed as a reference center for international clinical research in 2013. An LBI HF study on improved heart failure diagnosis using echocardiography and biomarkers was completed early. With INTENSE-HF (Integrated Telemonitoring and Nurse Support Assessment in Heart Failure), LBI HF has launched the largest ever telemedicine study in heart failure in Austria (press conference in Vienna). Telemedicine care for heart failure patients using smartphones and NFC technology (data transfer from blood pressure monitors, scales) combined with biomarkers should allow early detection of heart failure exacerbations at home 1. Hohendanner F, Ljubojevic S, Macquaide N , Sacherer M, Sedej S, Biesmans L, Wakula P, Platzer D, Sokolow S, Herchuelz A, Antoons G, Sipido K, Pieske B, Heinzel FR. Cardiac remodeling and intracellular asynchrony of cytoplasmic diastolic [Ca2+] decay in ventricular cardiomyocytes in human heart failure. Circ Res 2013;113(5): Sedej S, Schmidt A, Denegri M, Walther S, Matovina M, Arnstein G, Gutschi EM, Windhager I, Ljubojević S, Negri S, Heinzel FR, Bisping E, Vos MA, Napolitano C , Priori SG, Kockskamper J, Pieske B. Subclinical abnormalities in Ca2+ release from the sarcoplasmic reticulum promote eccentric myocardial remodeling and death from pump failure induced by pressure overload. J Am Coll Cardiol Nov 21, pii:S(13) doi:/j. jacc [Epub ahead of print] 3. Edelmann F, Wachter R, Schmidt AG, Kraigher-Krainer E, Colantonio C, Kamke W, Duvinage A, Stahrenberg R, Durstewitz K, Loffler M, Dungen HD, Tschope C, Herrmann-Lingen . C, Halle M, Hasenfuss G, Gelbrich G, Pieske B. Aldo-DHF investigators. Effects of spironolactone on diastolic function and exercise capacity in heart failure patients with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA 2013; 309(8): Schreier G, Schwarz M, Modre-Osprian R, Kastner P, Scherr D, Fruhwald F. Design and evaluation of a health-based multimodal medication management system for patient self-management. Conf Proc IEEE Eng Med Biol Soc, Perl S, Stiegler P, Rotman B, Prenner G, Lercher P, Anelli-Monti M, Sereinigg M, Riegelnik V, Kvas E, Kos C, Heinzel FR, Tscheliesnigg KH, Pieske B. Collaboration Partner - Economic impact and potential cost savings of remote monitoring of patients (SAVE-HM trial). International Heart Journal. 2013, 169(6): Austrian Institute of Technology (AT) Bayer HealthCare (DE) Karl-Franzens-University of Graz (AT) Medical University of Graz (AT) Steiermark Regional Health Insurance Fund (AT) Steiermärkische Krankenanstalten GesmbH (AT) Committee Prof. Dr. MD Georg Ertl Institute of Internal Medicine, University Hospital Würzburg (Germany) Prof. Dr. Arno W. Hoes Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht (Netherlands). Dr. Roberto Latini Institute of Pharmacology Prof. Mario Negri (IT) Dr. a Vera Regitz-Zagrosek Center for Cardiovascular Research, Charité Berlin (DE) Prof. Ajay Shah MD FRCP FMedSci King's College London (UK) Watch a video about the Institute 54 Ludwig Boltzmann Institute LBI Translational Heart Failure Study 55

29International Symposium, War, Memory Culture and Film Media Collection Vienna Family Film Day 2013 WB, LBIGGe, OeFM, VKM Ludwig Boltzmann History Cluster History Cluster: Structure and Objectives The Ludwig Boltzmann History Cluster (LBC) is one of the largest institutions. Austrian University of Contemporary History Center, consisting of the following four Ludwig Boltzmann Institutes: Institute of Social and Cultural History in Graz (LBI GKG), Institute of History and Society in Vienna (LBI GGe) , Social Sciences (LBI HS) in Vienna and LBI for the Study of War Consequences (BIK) in Graz. Cluster institutes are more intensively involved in teaching and research at the universities in which they are located, through the institutional positions and teaching activities of their directors. Through numerous research projects, long-term partnerships and conferences, the Cluster Institute is well-established and permanently integrated into international research networks in its main fields of work. The History Cluster, which has been in existence since 2005, is dedicated to the research and dissemination of Austrian and European history with a focus on the 20th century. It conducts fundamental and applied research with transnational references, innovative historical theoretical and methodological problems and solutions. His main areas of work are: 1. War, War Aftermath, Military 2. Social, Media and Cultural Memory 3. Democratic Crisis, Dictatorship, Genocide, Holocaust 4. Migration, Integration, Memory 5. Historical, Cultural and Scientific Method Social and Theoretical Review of Activities and Perspectives in 2013 In implementing the recommendations of the 2012 International Evaluation Committee, the cluster's joint activities focused on holding international colloquiums, with particular attention to the mentoring role of the participating senior researchers. The following symposiums were held: LBC International History Symposium New research organized in cooperation with the University of Graz and the Austrian-Russian Council of Historians (ÖRHK) in Graz focuses on the contemporary history of Central and Eastern Europe. The symposium LBC International History 1000 Wehrmacht events, assessments, memory and research in Lidice in Kalavryta and elsewhere focuses on dictatorship, violence and genocide at the University of Vienna and the Diplomatic Academy Vienna. Taking into account the experience of these first symposiums, for the next two working years the following topics will be the subject of the cluster's activities: The Intellectual Concept of the Post-War European Order Voters and Terrorist Activists of the NSDAP in Germany and Austria: New research finds and reassesses National Socialist concentration camps as spaces of social relations among prisoners of war, deportation and emigration World War I: Austria's front-line experience in the Cold War 1945-1991 In addition, inter-institutional Cooperation and knowledge exchange are enhanced at conferences, for example during World War I (Budapest, coordinator W. Dornik). The First World War is one of the core areas of the retrospective's annual work (e.g. preparations for 2014 exhibitions such as Die Steiermark und der Große Krieg and Jubel und Misery in Schallaburg; collection of private memorabilia). In addition, research in existing academic fields such as violence and space, the Cold War, the collapse of the Soviet Union, immigration, and the culture of memory continued, and methodological debates in the field of digital humanities deepened. Individual activities of the Cluster Institute include (selection): Presentation of the website of the film collection media wien/Wiener Stadt- und Landesarchiv at the Vienna City Hall, (Conference Roots of the Disintegration of the USSR and Eastern Aspects of the Economic Bloc (1989/91), Warsaw, Conference Living with the Great War The First World War in a Global Perspective in Kloster UND, Krems an der Donau, Conference 70 Years Moscow Declaration, Moskva, 25. Maderthaner (ed.): The Road to the Abyss, Responding to the Crisis of the 1930s (= International Social Historical Studies 21), New York, Oxford: Berghahn Books, 230 pp. Ludwig Boltzmann Cluster History Cluster Coordinator Helmut Konrad Institutts Director: 3 Main studies Personnel: 16 Postdocs: 3 Doctoral students: 14 Diploma students: 4 Master students: 1 Scientific staff: 25 Personnel management: 4 Assistants: 1 Other contractors: 1 University of Vienna (AT) University of Graz (AT) Watch a movie about star clusters Image: Lunghammer 2. Siegfried Mattl, Vrääth Öhner: The Aesthetics of the Possible: The Green Cockatoo as Bricolage of Heterogeneous Traditions, in: Ryan Shand/ Ian Craven (ed. .): A small-bore narrative. Discover Amateur Fiction Film, 2013 Edinburgh, S Cornelius Lehguth, Waldheim and Consequences. Party Leadership in National Socialism in Austria (Historical Social Science Research, 35, published by Gerhard Botz and Josef Ehmer with Peter Becker et al.), Frankfurt/M. - New York 2013, Bernhard Bachinger, Wolfram Dornik (ed.): Beyond the Trenches. World War I in the East: Experience Perceptual Context. Innsbruck Vienna. Bozen Dieter Bacher, Stefan Karner (ed.): Forced labor in Austria and its postwar fate. Results of the evaluation of the Austrian Reconciliation Fund document. preliminary report. Innsbruck Vienna Bozen Ludwig Boltzmann Cluster LBC History 57

30Ludwig Boltzmann Cardiovascular Research Group Findings, Highlights and Perspectives Aortic Flow In the ASC project, the influence of velocity modulation on optimal ventricular washout in flow studies was investigated. The role of transvalvular stents has been demonstrated in the hearts of single large animals. The perfusion solution was studied in collaboration with the REM project. This work accompanies the development of new minimally invasive implantation methods currently being developed at the Ludwig Boltzmann Cardiovascular Research Cluster (LBC Cardio) to reduce surgical trauma. Patient education was evaluated in a clinical study, correlating available pump parameters with ultrasound diagnosis, and the world's first continuous data recording was performed on an outpatient basis using a newly developed data logger. The BIO project examined biomarkers and copeptin, adrenomedullin, and pro-ANP in consecutive patients with chest pain/dyspnea in the emergency department. Patient enrollment was completed in November 2013. Articles are expected to be published in 2014 and 2015. In the CICAD study, more than 20 patients undergoing stenting ± acute coronary syndrome were investigated for circadian changes in platelet function tests. Patient enrollment is expected to be completed by mid-2014, with publication by the end of the year. Among patients with acute coronary syndrome receiving clopidogrel, prasugrel, or ticagrelor, all potential patients were screened based on the percentage of low responders or non-responders to the corresponding regimen. The study of clopidogrel began in 2013 and plans to begin enrolling patients taking either prasugrel or ticagrelor in 2014. The role of IL-33 in adipogenesis in IL-deficient mice was investigated as part of the INFO project. Preliminary results showed impaired glucose tolerance and increased inflammatory macrophage density in adipose tissue of IL-33 knockout mice. The construction of the human adipose tissue bank was completed. Sample analysis is planned to begin in 2014. A special issue of the Journal of Thrombosis and Hemostasis entitled Obesity and Vascular Disease: From Bench to Bedside is published by Guest Editor Johann Wojta. A review article on the role of so-called adipokines in the development of cardiovascular disease was also notably published there. In the REM project, in collaboration with King's College London, UK, the short-acting beta-blocker esmolol and a mixture of adenosine and magnesium were tested in a large animal model to achieve polarized cardiac arrest. The results of the research are presented nationally and internationally. In addition, a mouse click overload model is established. The ascending aorta of mice was constricted using microtomy. Subsequently, the animals showed signs of cardiac hypertrophy. After successful establishment, the effect of the matrix protein tenascin C on pressure overload was investigated. The purpose of this project is hemodynamic, functional and molecular biological characterization. In an SDG project, prosthetics made of slowly degrading biodegradable polycarbonate were tested in animal models. The grafts showed little degradation after long-term use. At the Vienna University of Technology, synthetic chemistry experiments were carried out to increase the degradation rate of the material. In collaboration with INFO, an in vitro co-culture and test assay of macrophages and fibroblasts was established to study biodegradable materials. Using a newly developed electrokinetic fiber alignment method, vascular prostheses with different fiber alignments were produced. The goal is to adapt the configuration to the vessel to be replaced, since all synthetic grafts have very little circumferential extension. Heart wear thumb-size minipump with Vienna cannula 1. Bergmeister H, Schreiber C, Grasl C, Walter I, Plasenzotti R, Stoiber M, Bernhard D, Schima H. ​​Healing properties of electrospun polyurethane grafts with different porosities. Acta Biomater Apr;9(4): Freynhofer MK, Bruno V, Brozovic I, Jarai R, Vogel B, Farhan S, Hübl W, Willheim M, Wojta J, Huber K. Changes in platelet reactivity during clopidogrel therapy. Platelets August 23. [Epub ahead of print] 3. Moscato F, Wirrmann C, Granegger M, Eskandary F, Zimpfer D, Schima H. ​​Continuous-flow ventricular assist device in heart failure patients with normal ejection fraction: a computer simulation Research. J Thorac Cardiovasc Surg May; 145 (5): Rega-Kaun G, Kaun C, Wojta J. More than just a storage organ: adipose tissue as a source of adipokines in cardiovascular disease. Thromb Haemost Oct; 110(4): Trescher K, Hasun M, Baumgartner A, Dietl W, Wolfsberger M, Hallstrom S, Podesser BK. The novel HTK-N46B cardioplegia provides superior protection during ischemia/reperfusion in heart failure. J Cardiovasc Surg (Turin) Jun;54(3): Ludwig Boltzmann Cardiovascular Research Cluster Department of Biomedical Research, AKH -1Q Währinger Gurtel 18 20, 1090 Wien, heinrich.schima Coordinator Cluster Univ.-Prof. Dr. Johann Wojta Deputy Coordinator of the Cluster Univ.-Prof. Dr. Di Heinrich Schima Principal investigators: 5 PhD students: 8 Diploma students: 2 Scientific experts: 1 Administrative staff: Assistant: 1 Other self-employed: 3 Medical University of Vienna (AT) Vienna Hospital Association (AT ) Committee Advisory Board Dr. Georg Fischer AOP Huérfano (AT) University Professor. Dr. Günter Laufer MD. University of Vienna (AT) University - Prof. Dr. Udo lost. University of Vienna (AT) University - Prof. Dr. Gerald Maurer with. University Vienna (AT) University - Professor Dr. Konrad Steinbach ASEP (AT) University Professor. Dr. Ernst Wolfner Medical University. Vienna (Austria) Watch a film about clusters 58 Ludwig Boltzmann Cluster LBC Cardiovascular Research 59

31Ludwig Boltzmann Cluster Oncology Identification and Characterization of Molecular Targets of Cancer Stem Cells in Myeloid Neoplasms A C Bone Marrow Microenvironment and Stem Cell Niche A: CD51-Positive Osteoclasts B: Myeloid Antibodies against Endosteal Cells in the Bone Marrow and Endosteal System: Bone Marrow - Endosteal cells: Bone marrow sections stained with KIT D antibody D: Mast cell leukemia: Bone marrow smears stained with Wright-Giemsa solution In 2013, Ludwig Boltzmann Cluster Oncology (LBC ONC) was able to complete many subprojects, including this year, The study of cancer stem cells (LSC) became the focus of these projects. The following results were obtained: B D LBC ONC proposes a new model for cancer stem cell development Over the past three years, LBC ONC developed a new model for LSC evolution. The new concept points out that not all cancer stem cells can simultaneously form expanded subclones. So-called precancerous tumor stem cells are partially quiescent cells that, despite their potential for further malignant transformation, do not have tumorigenic potential for a certain period of time. The model explains why leukemias or tumors often appear completely cured at first, how and why stem cell subclones are heterogeneous, and why relapse often only occurs years later. Some of these models have been developed in collaboration with the best international experts. The first work in this direction was published in the professional journal Nat Review Cancer in 2012. In 2013, this concept was further expanded with particular attention to the clinical implications and possible applications of the new model. The corresponding work was published in the journal Cancer Res in 2013. CD25 Regulation and Potential Role in CML and ALL Stem Cells Phenotypic characterization of CML stem cells has been performed in recent years by LBC ONCs. CD25 occupies a special place among numerous more or less specific targets and structures, since STAT5 target genes are clearly affected here. The LBC ONC project showed that STAT5 induces CD25 expression in LSCs. In addition, studies at LBC ONC have shown that CD25 regulates the growth of CML cells. This opens up new potential strategies to eliminate CML LSCs via CD25. Some ALL LSCs also express CD25 here, mainly in Ph+ ALL. Regulation of Campath-1 (CD52) Expression in Leukemic Stem Cells In recent years, the LBC ONC has been able to identify a number of novel stem cell antigens that are more or less specifically expressed in acute myeloid leukemia LSC (AML). This also includes Campath I antigen (CD52). This antigen serves not only as a marker but also as a target structure. Data collected from LBC ONCs demonstrated that the RAS signaling pathway specifically induces CD52 expression in LSCs. Establishment of stem cell lines as an alternative to animal experiments A central theme and goal of the LBC ONC is the establishment of stem cell lines that reflect primary LSC function and target gene expression patterns. LBC ONC also hopes to contribute to the development of new targeted therapies. In fact, LBC ONC has successfully established multiple LSC-like stem cell lines. An important aspect is that studies on these cell lines lead to a reduction in the number of animal experiments. This can be explained by the fact that with these new LSC lines, the necessary animal experiments can be planned more accurately and precisely. For example, using a newline terminates some screen attempts with the mouse. Outlook for 2014 In 2014, the validation of LSC targets (CD25, CD52, BRD4, STAT5) will advance and the study of the stem cell niche will become more important. The focus is on CSL in myeloid leukemia and mast cell leukemia. Different programs promote other alternatives to animal testing. 1. Valent P, Bonnet D, Woehrer S, Andreeff M, Copland M, Chomienne C, Eaves C: Cancer stem cell heterogeneity: theoretical, functional, and clinical implications. Cancer Res 2013;73: Gleixner KV, Peter B, Blatt K, Suppan V, Reiter A, Radia D, Hadzijusufovic E, Valent P: Effect of ponatinib and midostaurin (PKC412) on tumor mast cells carrying KIT D816V synergistic growth inhibitory effect. Haematologica 2013;98: Sperr WR, Kundi M, Wimazal F, Nösslinger T, Schönmetzler-Makrai A, Stauder R, Krieger O, Neukirchen J, Germing U, Pfeilstöcker M, Valent P: Proposed survival in patients with myelodysplastic syndromes score. Eur J Clin Invest 2013;43: Karlic H, Herrmann H, Varga F, Thaler R, Reitermeier R, Spitzer S, Ghanim V, Blatt K, Sperr WR, Valent P, Pfeilstöcker M: Epigenetics in the regulation of apoptosis Role in myelodysplastic syndromes and acute myeloid leukemia. Crit Rev Oncol Hematol 2013 [Epub ahead of print] is in print. 5. Peter B, Hadzijusufovic E, Schuch K, Pickl WF, Willmann M, Valent P: Obatoclax, a broad-spectrum inhibitor of survival-associated Bcl-2 family molecules, induces apoptosis and growth arrest in lung tumor mast cells. J Leukoc Biol 2013 [Epub ahead of print] In print. Ludwig Boltzmann Cluster Oncology Medical University of Vienna Währinger Gurtel 18 20, 1090 Vienna Cluster Coordinator (Scientific Management) University Professor. Dr. Peter Valent Cluster Deputy Coordinator and Administrative Manager Univ.-Prof. Dr. Thomas Grunt Principal Investigator: 1 Postdoc: 4 Doctoral Students: 1 Administrative Staff: 1 Medical University of Vienna (AT) Hanusch Hospital Wien (AT) COMMITTEES Scientific Advisory Committee Dr. a Dominique Bonnet Hematopoietic Stem Cell Laboratory (UK) Dr. Jos Jonkers Cancer Institute Professor, Netherlands (NL). Dr. Charles Theillet Institut de Recherche en Cancerologie de Montpellier (France) Watch a film about cluster 60 Ludwig Boltzmann Cluster 61 LBC Oncology

32Ludwig Boltzmann Cluster Rheumatology, Balneology and Rehabilitation Additive effect on rehabilitation of hospitalized patients. By the end of 2013, half of the planned cases had been included. IL-6 (ng/ml) Mimics LPS 1 µm 10 µm 100 µm 2.0 1.5 1.0 0.5 0.0 Studies on sulfur and NMR as therapeutic agents for degenerative occupational diseases (Institute for Lung and Lung Diseases)a) Ludwig Bohr Zemann Cluster Rheumatology, Balneology and Rehabilitation (LBC RBR) investigates the molecular mechanisms of action of sulfur (H2S) healing and its application in the treatment of degenerative rheumatic diseases (osteoarthritis). In order to investigate the role of H2S in physiology, pathophysiology (inflammation) and regeneration (cartilage and bone formation), in vitro (cell culture) and in vivo experiments were performed in mouse models of arthritis. 5a * * Anti-inflammatory effects of RAW b H2S releasing substances (5a, 5b, 8a and 8l). The RAW264.7 mouse macrophage cell line was pretreated with increasing concentrations (1100 µM) of these substances and then stimulated with lipopolysaccharide (LPS) for 24 hours. LPS causes macrophages to spontaneously release cytokines such as IL-6 and TNF-α. Compounds 5a, 8a and 81 significantly inhibited IL-6 production. Due to its very short half-life and toxicity, the classic H2S donor NaHS is only conditionally suitable for therapeutic use (in the form of sulfur baths). Therefore, there is interest in substances that release H2S slowly under controlled conditions, for example by thiol-induced H2S release, such as B. cysteine. In collaboration with the University of Exeter (UK) and Washington State University (USA), the effects of these substances on various cellular systems (fibroblasts, monocytes, macrophages) were studied. In experiments with monocytes and macrophages, 8a******8l*** cells were stimulated with bacterial lipopolysaccharide to simulate an inflammatory response. Some of these substances significantly inhibit the release of pro-inflammatory cytokines such as IL-6 and TNF-α. If the in vitro results are confirmed in further experiments, the most effective compounds will be tested in an animal model (collagen-induced arthritis). In studies performed to date, effects at the cellular level could be observed in this model by using NaHS; however, clinical symptoms were not significantly improved, possibly due to the unfavorable pharmacokinetic properties of NaHS. The work of the LBC RBR Institute for Medical Disease Rehabilitation (Saalfelden) focuses on improving the perception of pain and loss of function in patients with osteoarthritis. A study of the therapeutic use of magnetic resonance imaging (MSRT) and mechanical stress aimed to show whether different therapies for osteoarthritis combined with mild mechanical stimulation could optimize hospital rehabilitation. Cellular experiments carried out in collaboration with the Medical Universities of Vienna and Graz show that the osteoarthritis disease-modifying drug diacetin suppresses the inflammatory response through different receptor proteins, but the effect of mechanical stimulation on the expression of genes induced by the cytokine IL-1 get maintained. constant. KSRT affects Ca 2+ signaling and phosphokinase phosphorylation. The effect of KSRT on VAS (0-10 ) publication of data evaluation of patients with osteoarthritis, pain and disability after KSRT received the 2013 Pain Research Award from the Austrian Pain Society. * p < .01 ** p < 0, ** ** ** ** ** ** ** ** ** ** ** Knee Arthrosis Knee Arthrosis Low Back Pain KSRT Posterior Ankle Baseline6 - 8 weeks 6 months 12 months Pain (VAS) within one year after MRI treatment of knee, hip, back, ankle osteoarthritis (multicenter patient data) Results of cell culture experiments on mechanical stress and inflammatory process in order to analyze New insights into the rehabilitation of an increasing number of obese patients with joint problems. An ongoing epidemiological research project at the Baden Research Center is investigating the direct costs of shoulder soft tissue disease (periarticular disease) and patient recruitment is scheduled to be completed in 2014. 1. Kloesch B, Becker T, Dietersdorfer E, Kiener H, and Steiner G (2013) Anti-inflammatory and apoptotic effects of polyphenolic curcumin on human fibroblast-like synoviocytes. Immunopharmaceuticals International. 15. Kullich, W., Overbeck, J., and Spiegel, H.U. (2013) A one-year study of multicenter data on more than 1,000 patients with degenerative rheumatic disease undergoing therapeutic magnetic resonance imaging. J. Back musculoskeletal. rehabbed 26, Kullich, W., Stritzinger, B., Arnold M., Schwann, H., & Mur, E. (2013) Effectiveness of GammaSwing dynamic lengthening therapy in inpatient rehabilitation of patients with low back pain. Physical Rehabilitation Medicine. cura 23, ** ** * ** ** ** Ludwig Boltzmann Group for Rheumatology, Balneology and Rehabilitation Kurbadstraße 14, 1100 Wien Group Coordinator Univ.-Prof. Dr. Günter Steiner Cluster Deputy Coordinator Dr. Burkhard Klösch Principal Investigator: 1 PhD student: 1 Master student: 1 Research staff: 5 Administrative staff: 1 Pension Insurance Institute (AT) Wien-Oberlaa Arthritis Center (AT) Lower Austria Region Hospital Foundation (AT) Medical University of Vienna (AT) ) Vienna City Hospital Association (AT) Watch a film about the cluster62 Ludwig Boltzmann cluster LBC Rheumatology, balneology and rehabilitation63

33Ludwig Boltzmann Cluster Translational Oncology Clinical Trials, Translational Research and Development of a Comprehensive Oncology Database The Ludwig Boltzmann Cluster Translational Oncology (LBC TO) aims to transfer knowledge from basic and applied research to oncology practice. The focus is on minimal residual disease in cancer that is clinically unrecognized and often leads to relapse after apparently effective treatment. Treatment-resistant cells, which often resemble stem cells, are studied using molecular and cell biology research methods as well as clinical cancer therapies. In clinical studies, the effectiveness of new drugs has been evaluated against cancer cells, primary tumors, and metastases in a variety of solid tumors. The relationship between circulating tumor cells (CTCs), tumor response, progression-free time, and survival in patients with pancreatic, colon, and breast cancer was investigated. The focus is on translational aspects, especially the development of research protocols with an integrated translational research plan. This makes it possible to bridge the gap between preclinical and clinical research. Novel diagnostic and prognostic biomarkers were tested in 300 patients to identify colorectal cancer patients at high risk of recurrence and to stratify high-risk patients. Another goal is to elucidate the mechanisms leading to multidrug resistance. Modulation/reversal of chemoresistance in small cell lung cancer cells and ovarian cancer cells was studied. This includes analysis of stress response, use of other cytotoxic drugs including organometallic chemotherapeutics active against platinum resistant cells, modulators of pharmaceutical cytotoxicity such as ethyl dichloroacetate/CDK inhibitors and cyclophilin inhibition . LBC TO conducts clinical and translational research in the form of clinical trials to develop new molecules with antitumor activity. The group is involved in clinical studies with and without integrated pathological and radiological (molecular) diagnosis, pharmacokinetics, drug toxicity evaluation and retrospective studies of tumor clinical characteristics, as well as prognostic and diagnostic biomarkers involved in pharmacoeconomic studies evaluation of things. Cancer therapy has been applied to many solid tumor entities such as breast and urogenital B. cancers, gynecological and gastrointestinal tumors, non-small cell lung cancer, squamous cell carcinoma of the head and neck, glioma, and lymphoma. Two new members of the Wien Donauspital contribute their expertise and facilitate access to biological materials: Univ.-Prof. Angelika Reiner (Institute of Pathology and Bacteriology) and University Professor. Walter Hruby (Institute of Diagnostic X-Ray). A branch was established to supply biomaterials and conduct translational research and clinical trials. twelve. Christoph Ausch becomes Director of Surgery at the Kirchdorf and Steyr hospitals, both university teaching hospitals. A comprehensive clinical database/tumor bank is being developed, which will be merged with the LIMS/specimen management database operated jointly with the Molecular Oncology Research Laboratory of the Medical University of Vienna. Together with the Joint Tumor Bank, the database will represent the backbone of patient-relevant experimental research. Outlook Given the advances in circulating tumor cells (CTCs), viz. ie. To identify cyclophilin C as a prognostic biomarker in ovarian cancer, the therapeutic relevance of various cyclosporine A analogs will be investigated in cell line models. Multiple multicenter clinical studies are planned, including studies using CTCs as biomarkers. 1. Buchner P, Mihola E, Sahmanovic A, Steininger T, Dittrich C, Czejka M. Validation of a simple assay for the quantification of capecitabine metabolites 5-DFCR and 5-DFUR for drug monitoring in patients receiving chemotherapy Ambulatory Anticancer Res. 33, 2013 (IF 1713) 2. Buxhofer-Ausch V, Ausch C, Zeillinger R, Oberkanins C, Dandachi N, Reiner-Concin A, Kriegshäuser G. Double reverse hybridization assay for simultaneous detection of KRAS/mutations on extracted genomic DNA BRAF uses FFPE from colorectal cancer samples. show. Markers 2013;34(3): Hamilton G, Olszewski U. (2013) Picoplatin pharmacokinetics and chemotherapy in non-small cell lung cancer. Expert Opinion Drug Toxicology Metabolism. 9 Hamilton G, Olszewski U, Klameth L, Ulsperger U, Geissler K (2013) Synergistic anticancer activity of a combination of topotecan cyclin-dependent kinase inhibitors against drug-resistant small cell lung cancer (SCLC) cell lines. J Cancer Therapy 4: Obermayr E, Castillo-Tong DC, Pils D, Speiser P, Braicu I, Van Gorp T, Mahner S, Sehouli J, Vergote I, Zeillinger R. Molecular characterization of circulating tumor cells in cancer patients with ovarian cancer. Improving its prognostic significance: an OVCAD joint study. Gynecol Oncol Jan;128(1): Ludwig Boltzmann Cluster Translational Oncology Währinger Gurtel 18 20, Leitstelle 5Q, 1090 Wien Cluster Coordinator Dr. Univ.-Prof. Prof. Robert Zeilinger University. Dr. Gerhard Hamilton Institute Leadership: 4 Principal Investigators: 1 Postdoc: 8 Doctoral Students: 3 Diploma Students: 2 Scientific Specialists: 4 Administrative Staff: 4 Assistants: 2 Other Contractors: 2 other researchers: 1 Medical University of Vienna (AT) Wiener Krankenanstaltenverbund (AT) Watch a movie about clusters 64 Ludwig Boltzmann Cluster LBC Translational Oncology 65

34LUDWIG BOLTZMANN Institute 2013 LBI Archaeological Survey and Virtual Archeology_/ Director: Wolfgang Neubauer / LBI COPD and Pulmonary Epidemiology_/ Director: Otto C. Burghuber / LBI Electrical Stimulation and Physical Rehabilitation_/ Director: Clinic Kern and Experiment: Clinic Kern and Experiment. , Albert Kröpfl / LBI History and Biographical Theory_/ Director: Wilhelm Hemecker / LBI Health Promotion Research_/ Director: Wolfgang Dür / LBI Health Technology Evaluation_/ Director: Claudia Wild / LBI Clinical-Forensic Imaging_/ Director : Eva Scheurer / LBI Cancer Research_ / Director: Richard Moriggl / LBI Pulmonary Vascular Research_ / Director: Andrea Olschewski / LBI Human Rights_ / Director: Hannes Tretter, Manfred Nowak / LBI Neulatin Studies_ / Director: Stefan Tilg / LBI Surgical Laparoscopy_/ Director: Wolfgang Wayand / LBI Osteology_/ Director: Klaus Klaushofer / LBI Retinology and Biolaser Microsurgery_/ Director: Susanne Binder / LBI Social Psychiatry_/ Director: Heinz Katschnig / LBI Translational Heart Failure Research_/Head: Burkert Pieske/The following LBI completed research activities at LBI Europe History and Public 2013 Sphere_/ Head: Thomas Lindenberger / LUDWIG BOLTZMANN ORGANIZATIONS 2013 Airborne Technologies AIT Austrian Institute of Technology General Accident Insur ance Institution Linz City General Hospital Lower Austria Provincial Government Office Bayer HealthCare Bayer Pharma AG Bixa TechnoConsulting Federal Ministry of Health Federal Ministry of the Interior Education, Arts and Culture Health Austria GmbH Healthy Austria Fund Health funds of the nine federal states The main association of Austrian social insurance companies IMP - Institute of Molecular Pathology Health Insurance Norwegian Institute of Cultural Heritage NIKU Higher Regional Court Graz Austrian National Library Steiermärkische Regional Health Insurance Fund Steiermärkische Krankenanstalten GesmbH Vienna Technical University Center for Visual and Spatial Technology VISTA TissueGnostics Bielefeld University University of Freiburg University of Graz Innsbruck University St. Johann's University Andrews University Vienna University Hospital Heidelberg University LUDWIG BOLTZMANN CLUSTER 2013 History Cluster_/ Coordinator: Helmut Konrad / Cardiovascular Research Cluster_/ Coordinator: Johann Wojta / Oncology Cluster_/ Coordinator Members: Peter Valent, Thomas Grunt / Rheumatology, Balneotherapy and Rehabilitation Cluster_/ Translation Cluster_ / Translation Cluster_ / Translation Coordinator: / Stein Cluster Coordinator: / Robert Zeillinger, Gerhard Hamilton / 66 Ludwig Boltzmann Institutes and Cluster 2013 Ludwig Boltzmann Partner Organizations

352013 Facts and Figures

36Ludwig Boltzmann LBG staff Overview of the 2013 LBG budget The 2013 LBG budget was €29.9 million. Legal Form Discipline LBG Total LBG Verein LBG GmbH Medizin/LS GSK FTE No. FTE No. FTE No. FTE No. FTE No. Real DN , , , , , ,35 Free DN ,88 6 2, ,01 7 2, , 31 Employment Contract Total, , , , ,66 10% 3% 22% Female Austrian male% EU citizen (except Austria) Unspecified third country national d. Nationality% 16% DN: Employees FTE: Full-time equivalent LS: Life sciences GSK: Humanities, society and Culture Sciences 14% 15% 3% LBG Distribution by Manager and Contract Type Ratio Between Science and Science Non-Science Personnel in National Foundations LBG BMF % City of Vienna Federal Government, Federal States, Municipalities (except Vienna) 436 European Union +Other international organization funding agencies (FWF, FFG,) % Other. Public bodies (companies, foundations, foundations, museums) Private companies (associations, donations) Real DN Free DN Work contract Scientific Non-scientific 70 Facts and Figures Percentages given are rounded to whole numbers. Percentages given are rounded to the nearest whole number. Facts and Figures 71

37Society Ludwig Boltzmann 2013 LBG Visiting Scientist Visiting Researchers Educational Level Functional Department Director LBG Research Institute Principal Investigator 18% 8% 3% 3% 13% Master's Student Doctoral Postdoctoral Researcher 10% 10% *Scientist Research Staff Administration Other staff 55 % 30% * Scientific specialist: Biomedical analyst Technical-chemical assistant Technical-medical specialist Technical specialist 50% The composition of invited scientists and scientific research personnel Undergraduates 2% 28% 3-6 within 3 months Months 6-12 months 5% Master students 10% Master students 4% 35% 60% PhD students 30% Postdoctoral students 27% 0% 5% 10% 15% 20% 25% 30% 72 Percentage of facts and figures stated Round to whole numbers. Percentages given are rounded to the nearest whole number. Facts and Figures 73

38Ludwig Boltzmann Society LBG Staff Scientific Activity Overview Third Party Funded Projects 2013 LBG Qualification Papers Number of Qualification Papers Completed at LBI/LBC 2013 6 Papers 12 Diploma Papers 26 Ludwig Boltzmann Institute 4 4 Boltzmann Papers 4 Boltzmann Papers 4 Boltzmann Papers: Ludwig Boltzmann Cluster Applications submitted Applications Approved LBG Appointments Appointments Number of Ongoing Projects Appointed to University's LBI/ in 2013 LBC Staff: Last Name, First Name, LBI/LBC 3 Appointments: Casanova, Emilio LBI Cancer Research Medical University of Vienna (AT) LBG Kenner, Lukas LBI Cancer Research Moriggl, Richard LBI Cancer Research Teaching activities Medical University of Vienna and Vienna Veterinary University ( Dual appointment) (AT) Medical University of Vienna and Vienna Veterinary University (dual appointment) (AT) Seminars LBI: Ludwig Boltzmann Institute LBC: Ludwig Boltzmann Cluster lectures Internship/exercise 3% Other 31% LBG Assessor activities LBG 47% Professional journals 271 papers (Bakk. Dipl., Diss, Habil.) 209 Research grant applications 58 Research institution evaluations 34 19% Non-LBGs active on editorial boards: 46 Members of LBG committees in professional science and management: facts and figures show Percentages rounded to whole numbers Facts and numbers 75

39Legal Forms Discipline LBG Association LBG GmbH Medicine/LS GSK total Scientific Journal Articles* Scientific Monograph Collections Ludwig Boltzmann Society Publications Editorial Articles (including Conference Proceedings) Other Publications Policy Documents Top Scientific Publications Total* Including Peer Reviews not peers Reviewed Peer-Reviewed Articles LS: Life Sciences GSK: Humanities, Social Sciences and Cultural Studies Peer-Reviewed Articles in Life Sciences/Medicine Indexed Journals Peer-Reviewed Articles in Life Sciences/Medicine Indexed Journals Total Original Articles, Reviews and Other Articles 248 Original articles published by LBI/LBC staff as first or/and, last or/and as corresponding authors Articles published in the top 10% of journals in their respective research fields Number of review articles15 Other contributions (e.g. reviews)4 Due to indexed journals The importance or presence differs between medical/life sciences and human, social and cultural sciences, the table below shows only LBI and LBC digital specialists in medical/life sciences * 42 * * x LBG Weinherbst 100 x Discussion activities (club research ) 160 x 1st LBG Health Sciences Conference 300 x * Held 5 times a year** Average number of visitors event LBI/LBC events Number of science outreach events LBI/LBC is the main organizer of public events in which LBI/LBC participates Events LBC LBI: Ludwig Boltzmann Institute LBC: Ludwig Boltzmann Cluster. Average number of visitors at scientific events Average number of visitors Medicine/LS GSK Number of invited lectures Other lectures Posters Presentations LS: Life Sciences GSK: Humanities, Social Sciences and Cultural Sciences LBI: Ludwig Boltzmann Institute LBC: Ludwig Boltzmann PUBLIC Relations/Media Resonance Media coverage of LBG in 2013 Number of newspaper articles (print version) 380 online-only articles 90 radio stories 13 TV stories 7 LBG website visits 2013 page views generated unique visitors and figures Facts and figures 77

40Media owner/publisher Ludwig Boltzmann Society Nußdorfer Straße 64, 6th Floor 1090 Wien EDITION AND TEXT Public Relations Larissa Gruber with contributions from LBG researchers


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